Emergence of Elastic Properties in a Minimalist Resilin-Derived Heptapeptide upon Bromination

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Journal Title
Journal ISSN
Volume Title
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Date
2022-08
Major/Subject
Mcode
Degree programme
Language
en
Pages
10
2200807
Series
Small, Volume 18, issue 32
Abstract
Bromination is herein exploited to promote the emergence of elastic behavior in a short peptide—SDSYGAP—derived from resilin, a rubber-like protein exerting its role in the jumping and flight systems of insects. Elastic and resilient hydrogels are obtained, which also show self-healing behavior, thanks to the promoted non-covalent interactions that limit deformations and contribute to the structural recovery of the peptide-based hydrogel. In particular, halogen bonds may stabilize the β-sheet organization working as non-covalent cross-links between nearby peptide strands. Importantly, the unmodified peptide (i.e., wild type) does not show such properties. Thus, SDSY(3,5-Br)GAP is a novel minimalist peptide elastomer.
Description
Tallenna OA-artikkeli, kun julkaistu
Keywords
bromination, elastomers, halogen bonding, peptides, resilin, self-assembly, supramolecular chemistry
Other note
Citation
Pizzi , A , Sori , L , Pigliacelli , C , Gautieri , A , Andolina , C , Bergamaschi , G , Gori , A , Panine , P , Grande , A M , Linder , M B , Baldelli Bombelli , F , Soncini , M & Metrangolo , P 2022 , ' Emergence of Elastic Properties in a Minimalist Resilin-Derived Heptapeptide upon Bromination ' , Small , vol. 18 , no. 32 , 2200807 , pp. 2200807 . https://doi.org/10.1002/smll.202200807