A comparative cross‐platform meta‐analysis to identify potential biomarker genes common to endometriosis and recurrent pregnancy loss

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Journal Title
Journal ISSN
Volume Title
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Date
2021-04-02
Major/Subject
Mcode
Degree programme
Language
en
Pages
17
Series
Applied Sciences (Switzerland), Volume 11, issue 8
Abstract
Endometriosis is characterized by unwanted growth of endometrial tissue in different locations of the female reproductive tract. It may lead to recurrent pregnancy loss, which is one of the worst curses for the reproductive age group of human populations around the world. Thus, there is an urgent need for unveiling any common source of origin of both these diseases and con-nections, if any. Herein, we aimed to identify common potential biomarker genes of these two diseases via in silico approach using meta‐analysis of microarray data. Datasets were selected for the study based on certain exclusion criteria. Those datasets were subjected to comparative meta‐anal-yses for the identification of differentially expressed genes (DEGs), that are common to both diag-noses. The DEGs were then subjected to protein‐protein networking and subsequent functional enrichment analyses for unveiling their role/function in connecting two diseases. From the analyses, 120 DEGs are reported to be significant out of which four genes have been found to be prominent. These include the CTNNB1, HNRNPAB, SNRPF and TWIST2 genes. The significantly enriched pathways based on the above‐mentioned genes are mainly centered on signaling and developmental events. These findings could significantly elucidate the underlying molecular events in endometri-osis‐based recurrent miscarriages.
Description
Publisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
Keywords
Endometriosis, Functional enrichment, Meta‐analysis, Recurrent pregnancy loss, TWIST2 gene
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Citation
Guha , P , Roychoudhury , S , Singha , S , Kalita , J C , Kolesarova , A , Jamal , Q M S , Jha , N K , Kumar , D , Ruokolainen , J & Kesari , K K 2021 , ' A comparative cross‐platform meta‐analysis to identify potential biomarker genes common to endometriosis and recurrent pregnancy loss ' , Applied Sciences (Switzerland) , vol. 11 , no. 8 , 3349 . https://doi.org/10.3390/app11083349