A Janus-Type Phthalocyanine for the Assembly of Photoactive DNA Origami Coatings
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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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Date
2021-06-16
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en
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7
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Bioconjugate Chemistry, Volume 32, issue 6, pp. 1123–1129
Abstract
Design and synthesis of novel photosensitizer architectures is a key step toward new multifunctional molecular materials. Photoactive Janus-type molecules provide interesting building blocks for such systems by presenting two well-defined chemical functionalities that can be utilized orthogonally. Herein a multifunctional phthalocyanine is reported, bearing a bulky and positively charged moiety that hinders their aggregation while providing the ability to adhere on DNA origami nanostructures via reversible electrostatic interactions. On the other hand, triethylene glycol moieties render a water-soluble and chemically inert corona that can stabilize the structures. This approach provides insight into the molecular design and synthesis of Janus-type sensitizers that can be combined with biomolecules, rendering optically active biohybrids.Description
| openaire: EC/H2020/794536/EU//BiHyOMat Funding Information: We acknowledge the provision of facilities and technical support by Aalto University Bioeconomy Facilities and OtaNano – Nanomicroscopy Center (Aalto-NMC) and funding from the Jane and Aatos Erkko Foundation. The authors also thank Sofia Julin and Heini Ijäs from Department of Bioproducts and Biosystems, Aalto University, for providing DNA origami samples. IMDEA Nanociencia also acknowledges support from the “Severo Ochoa” Programme for Centres of Excellence in R&D (MINECO, grant SEV-2016-0686). Funding Information: We acknowledge the Academy of Finland (286845, 308578), the Magnus Ehrnrooth Foundation, and the Marie Sklodowska-Curie grant (794536). MINECO-Feder funds (CTQ2017-85393-P (TT), CTQ-2014-53673-P and CTQ-2017-89539-P (AdlE), and PCIN-2017-042/EuroNanoMed2017-191, TEMPEAT (TT)). Publisher Copyright: © 2021 American Chemical Society.
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Rahali, A, Shaukat, A, Almeida-Marrero, V, Jamoussi, B, de la Escosura, A, Torres, T, Kostiainen, M A & Anaya-Plaza, E 2021, ' A Janus-Type Phthalocyanine for the Assembly of Photoactive DNA Origami Coatings ', Bioconjugate Chemistry, vol. 32, no. 6, pp. 1123–1129 . https://doi.org/10.1021/acs.bioconjchem.1c00176