Discrete Ricci curvatures capture age-related changes in human brain functional connectivity networks
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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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19
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Frontiers in Aging Neuroscience, Volume 15, pp. 1-19
Abstract
Introduction: Geometry-inspired notions of discrete Ricci curvature have been successfully used as markers of disrupted brain connectivity in neuropsychiatric disorders, but their ability to characterize age-related changes in functional connectivity is unexplored. Methods: We apply Forman-Ricci curvature and Ollivier-Ricci curvature to compare functional connectivity networks of healthy young and older subjects from the Max Planck Institute Leipzig Study for Mind-Body-Emotion Interactions (MPI-LEMON) dataset (N = 225). Results: We found that both Forman-Ricci curvature and Ollivier-Ricci curvature can capture whole-brain and region-level age-related differences in functional connectivity. Meta-analysis decoding demonstrated that those brain regions with age-related curvature differences were associated with cognitive domains known to manifest age-related changes—movement, affective processing, and somatosensory processing. Moreover, the curvature values of some brain regions showing age-related differences exhibited correlations with behavioral scores of affective processing. Finally, we found an overlap between brain regions showing age-related curvature differences and those brain regions whose non-invasive stimulation resulted in improved movement performance in older adults. Discussion: Our results suggest that both Forman-Ricci curvature and Ollivier-Ricci curvature correctly identify brain regions that are known to be functionally or clinically relevant. Our results add to a growing body of evidence demonstrating the sensitivity of discrete Ricci curvature measures to changes in the organization of functional connectivity networks, both in health and disease.Description
Funding Information: AS would like to acknowledge research support from the Max Planck Society, Germany via a Max Planck Partner Group in Mathematical Biology and the Department of Atomic Energy (DAE), Government of India. JJ acknowledges support from the German-Israeli Foundation (GIF) grant number I-1514-304.6/2019. Publisher Copyright: Copyright © 2023 Yadav, Elumalai, Williams, Jost and Samal.
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Yadav, Y, Elumalai, P, Williams, N, Jost, J & Samal, A 2023, 'Discrete Ricci curvatures capture age-related changes in human brain functional connectivity networks', Frontiers in Aging Neuroscience, vol. 15, 1120846, pp. 1-19. https://doi.org/10.3389/fnagi.2023.1120846