Phthalate exposure and subfecundity in preconception couples : A nested case-control study
Loading...
Access rights
openAccess
publishedVersion
URL
Journal Title
Journal ISSN
Volume Title
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
This publication is imported from Aalto University research portal.
View publication in the Research portal (opens in new window)
View/Open full text file from the Research portal (opens in new window)
Other link related to publication (opens in new window)
View publication in the Research portal (opens in new window)
View/Open full text file from the Research portal (opens in new window)
Other link related to publication (opens in new window)
Date
2024-06-15
Department
Major/Subject
Mcode
Degree programme
Language
en
Pages
12
Series
Ecotoxicology and Environmental Safety, Volume 278, pp. 1-12
Abstract
Background: Phthalates (PAEs) are endocrine-disrupting chemicals ubiquitously found in the environment. This study aimed to examine the association between exposure of PAEs and subfecundity in preconception couples. Methods: This is a nested case-control study based on preconception cohort. Preconception couples with intention to conceive were enrolled and followed up until a clinically confirmed pregnancy or 12 menstrual cycles of preparation for conception. A total of 107 couples with subfecundity- time to pregnancy (TTP) more than 12 menstrual cycles, and 144 couples ≤12 cycles were included in the analysis. The levels of PAE metabolites in one spot urine samples were detected and compared between the groups. The weighted quantile sum (WQS) regression model and Bayesian kernel machine regression (BKMR) model were used to examine the joint effects of couples’ exposure to PAEs on subfecundity. Results: Using the multivariate binary logistic regression model, compared to the lowest quartile of urinary ∑PAEs concentration group, both preconception females (aOR=2.42, 95% CI: 1.10–5.30, p=0.027) and males (aOR=2.99, 95% CI: 1.36–6.58, p=0.006) in the highest quartile group had an increased risk of subfecundity, and a dose-response relationship was observed between PAEs and the risk of subfecundity. The WQS analyses found that co-exposure to PAE mixture was a risk factor for subfecundity in preconception female (aOR=1.76, 95% CI: 1.38–2.26, p<0.001), male (aOR=1.58, 95% CI: 1.20–2.08, p=0.001), and couple (aOR=2.39, 95% CI: 1.61–3.52, p<0.001). The BKMR model found a positive combined effect of mixed exposure to PAEs on the risk of subfecundity. Conclusions: PAEs increase the risk of subfecundity in preconception couples. Our research reinforced the need of monitoring PAE exposure for the purpose of improving human reproductive health.Description
Publisher Copyright: © 2024 The Authors
Keywords
Nested case-control study, Phthalate, Preconception couples, Subfecundity, Time to pregnancy
Other note
Citation
Yin, A, Mao, L, Zhang, C, Du, B, Xiong, X, Chen, A, Cheng, L, Zhang, Z, Li, X, Zhou, Y & Jiang, H 2024, ' Phthalate exposure and subfecundity in preconception couples : A nested case-control study ', Ecotoxicology and Environmental Safety, vol. 278, 116428, pp. 1-12 . https://doi.org/10.1016/j.ecoenv.2024.116428