Simultaneous investigation of the liquid transport and swelling performance during tablet disintegration

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorAl-Sharabi, Mohammed
dc.contributor.authorMarkl, Daniel
dc.contributor.authorMudley, Theona
dc.contributor.authorBawuah, Prince
dc.contributor.authorKarttunen, Anssi Pekka
dc.contributor.authorRidgway, Cathy
dc.contributor.authorGane, Patrick
dc.contributor.authorKetolainen, Jarkko
dc.contributor.authorPeiponen, Kai Erik
dc.contributor.authorRades, Thomas
dc.contributor.authorZeitler, J. Axel
dc.contributor.departmentUniversity of Cambridge
dc.contributor.departmentUniversity of Strathclyde
dc.contributor.departmentUniversity of Eastern Finland
dc.contributor.departmentOmya AG
dc.contributor.departmentDepartment of Bioproducts and Biosystems
dc.contributor.departmentUniversity of Copenhagen
dc.date.accessioned2021-04-20T06:50:01Z
dc.date.available2021-04-20T06:50:01Z
dc.date.embargoinfo:eu-repo/date/embargoEnd/2021-05-11
dc.date.issued2020-06-30
dc.description.abstractFast disintegrating tablets have commonly been used for fast oral drug delivery to patients with swallowing difficulties. The different characteristics of the pore structure of such formulations influence the liquid transport through the tablet and hence affect the disintegration time and the release of the drug in the body. In this work, terahertz time-domain spectroscopy and terahertz pulsed imaging were used as promising analytical techniques to quantitatively analyse the impact of the structural properties on the liquid uptake and swelling rates upon contact with the dissolution medium. Both the impact of porosity and formulation were investigated for theophylline and paracetamol based tablets. The drug substances were either formulated with functionalised calcium carbonate (FCC) with porosities of 45% and 60% or with microcrystalline cellulose (MCC) with porosities of 10% and 25%. The terahertz results reveal that the rate of liquid uptake is clearly influenced by the porosity of the tablets with a faster liquid transport observed for tablets with higher porosity, indicating that the samples exhibit structural similarity in respect to pore connectivity and pore size distribution characteristics in respect to permeability. The swelling of the FCC based tablets is fully controlled by the amount of disintegrant, whereas the liquid uptake is driven by the FCC material and the interparticle pores created during compaction. The MCC based formulations are more complex as the MCC significantly contributes to the overall tablet swelling. An increase in swelling with increasing porosity is observed in these tablets, which indicates that such formulations are performance-limited by their ability to take up liquid. Investigating the effect of the microstructure characteristics on the liquid transport and swelling kinetics is of great importance for reaching the next level of understanding of the drug delivery, and, depending on the surface nature of the pore carrier function, in turn controlling the performance of the drug mainly in respect to dissolution in the body.en
dc.description.versionPeer revieweden
dc.format.extent11
dc.identifier.citationAl-Sharabi , M , Markl , D , Mudley , T , Bawuah , P , Karttunen , A P , Ridgway , C , Gane , P , Ketolainen , J , Peiponen , K E , Rades , T & Zeitler , J A 2020 , ' Simultaneous investigation of the liquid transport and swelling performance during tablet disintegration ' , International Journal of Pharmaceutics , vol. 584 , 119380 . https://doi.org/10.1016/j.ijpharm.2020.119380en
dc.identifier.doi10.1016/j.ijpharm.2020.119380
dc.identifier.issn0378-5173
dc.identifier.issn1873-3476
dc.identifier.otherPURE UUID: c9ae844c-334a-4df2-bd44-193fa5c2b646
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/c9ae844c-334a-4df2-bd44-193fa5c2b646
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85085035154&partnerID=8YFLogxK
dc.identifier.otherPURE LINK: https://www.repository.cam.ac.uk/handle/1810/305855
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/106923
dc.identifier.urnURN:NBN:fi:aalto-202104206217
dc.language.isoenen
dc.publisherElsevier
dc.relation.ispartofseriesInternational Journal of Pharmaceuticsen
dc.relation.ispartofseriesVolume 584en
dc.rightsopenAccessen
dc.subject.keywordDisintegration
dc.subject.keywordLiquid transport
dc.subject.keywordMicrostructure
dc.subject.keywordPharmaceutical tablets
dc.subject.keywordPorous media
dc.subject.keywordSwelling
dc.subject.keywordTerahertz
dc.titleSimultaneous investigation of the liquid transport and swelling performance during tablet disintegrationen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
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