Resolving the rapid water absorption of porous functionalised calcium carbonate powder compacts by terahertz pulsed imaging

dc.contributorAalto Universityen
dc.contributor.authorMarkl, Danielen_US
dc.contributor.authorWang, Parryen_US
dc.contributor.authorRidgway, Cathyen_US
dc.contributor.authorKarttunen, Anssi Pekkaen_US
dc.contributor.authorBawuah, Princeen_US
dc.contributor.authorKetolainen, Jarkkoen_US
dc.contributor.authorGane, Patricken_US
dc.contributor.authorPeiponen, Kai Eriken_US
dc.contributor.authorZeitler, J. Axelen_US
dc.contributor.departmentDepartment of Bioproducts and Biosystemsen
dc.contributor.groupauthorPrinting Technologyen
dc.contributor.organizationUniversity of Cambridgeen_US
dc.contributor.organizationOmya International AGen_US
dc.contributor.organizationUniversity of Eastern Finlanden_US
dc.description.abstractCost effectiveness, ease of use and patient compliance make pharmaceutical tablets the most popular and widespread form to administer a drug to a patient. Tablets typically consist of an active pharmaceutical ingredient and a selection from various excipients. A novel highly porous excipient, functionalised calcium carbonate (FCC), was designed to facilitate rapid liquid uptake leading to disintegration times of FCC based tablets in the matter of seconds. Five sets of FCC tablets with a target porosity of 45-65% in 5% steps were prepared and characterised using terahertz pulsed imaging (TPI). The high acquisition rate (15Hz) of TPI enabled the analysis of the rapid liquid imbibition of water into these powder compacts. The penetration depth determined from the TPI measurements as a function of time was analysed by the power law and modelled for both the inertial (initial phase) and Lucas-Washburn (LW, longer time Laplace- Poiseuillian) regimes. The analysis of the hydraulic radius estimated by fitting the liquid imbibition data to the LW equation demonstrates the impact of the porosity as well as the tortuosity of the pore channels on the liquid uptake performance. The tortuosity was related to the porosity by a geometrical model, which shows that the powder compact is constructed by aggregated particles with low permeability and its principal axis perpendicular to the compaction direction. The consideration of the tortuosity yielded a very high correlation (R 2 =0.96) between the porosity and the hydraulic pore radius. The terahertz data also resolved fluctuations (0.9-1.3Hz) of the liquid movement which become more pronounced and higher in frequency with increasing porosity, which is attributed to the constrictivity of pore channels. This study highlights the strong impact of a tablet's microstructure on its liquid penetration kinetics and thus on its disintegration behaviour.en
dc.description.versionPeer revieweden
dc.identifier.citationMarkl, D, Wang, P, Ridgway, C, Karttunen, A P, Bawuah, P, Ketolainen, J, Gane, P, Peiponen, K E & Zeitler, J A 2018, ' Resolving the rapid water absorption of porous functionalised calcium carbonate powder compacts by terahertz pulsed imaging ', Chemical Engineering Research and Design, pp. 1082-1090 .
dc.identifier.otherPURE UUID: 9a083d5f-e122-497e-a9bd-f6b96091a180en_US
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dc.relation.ispartofseriesChemical Engineering Research and Designen
dc.subject.keywordFunctionalised calcium carbonateen_US
dc.subject.keywordLiquid imbibitionen_US
dc.subject.keywordPharmaceutical tabletsen_US
dc.subject.keywordPorous mediaen_US
dc.subject.keywordTerahertz pulsed imagingen_US
dc.titleResolving the rapid water absorption of porous functionalised calcium carbonate powder compacts by terahertz pulsed imagingen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi