Neural Mechanisms Underlying Human Auditory Evoked Responses Revealed By Human Neocortical Neurosolver

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Journal Title
Journal ISSN
Volume Title
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Date
2022-01
Major/Subject
Mcode
Degree programme
Language
en
Pages
17
19-35
Series
Brain Topography, Volume 35, issue 1
Abstract
Auditory evoked fields (AEFs) are commonly studied, yet their underlying neural mechanisms remain poorly understood. Here, we used the biophysical modelling software Human Neocortical Neurosolver (HNN) whose foundation is a canonical neocortical circuit model to interpret the cell and network mechanisms contributing to macroscale AEFs elicited by a simple tone, measured with magnetoencephalography. We found that AEFs can be reproduced by activating the neocortical circuit through a layer specific sequence of feedforward and feedback excitatory synaptic drives, similar to prior simulation of somatosensory evoked responses, supporting the notion that basic structures and activation patterns are preserved across sensory regions. We also applied the modeling framework to develop and test predictions on neural mechanisms underlying AEF differences in the left and right hemispheres, as well as in hemispheres contralateral and ipsilateral to the presentation of the auditory stimulus. We found that increasing the strength of the excitatory synaptic cortical feedback inputs to supragranular layers simulates the commonly observed right hemisphere dominance, while decreasing the input latencies and simultaneously increasing the number of cells contributing to the signal accounted for the contralateral dominance. These results provide a direct link between human data and prior animal studies and lay the foundation for future translational research examining the mechanisms underlying alteration in this fundamental biomarker of auditory processing in healthy cognition and neuropathology.
Description
Funding Information: This study was supported by National Institutes of Health (Grant Nos. NIBIB RO1 EB022889, NIMH RO1 MH106174). Publisher Copyright: © 2021, The Author(s).
Keywords
AEF, Auditory processing, Biophysical model, HNN, MEG
Other note
Citation
Kohl , C , Parviainen , T & Jones , S R 2022 , ' Neural Mechanisms Underlying Human Auditory Evoked Responses Revealed By Human Neocortical Neurosolver ' , Brain Topography , vol. 35 , no. 1 , pp. 19-35 . https://doi.org/10.1007/s10548-021-00838-0