Transferability of cathodal tDCS effects from the primary motor to the prefrontal cortex: A multimodal TMS-EEG study

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dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorMosayebi-Samani, Mohsenen_US
dc.contributor.authorAgboada, Desmonden_US
dc.contributor.authorMutanen, Tuomas P.en_US
dc.contributor.authorHaueisen, Jensen_US
dc.contributor.authorKuo, Min Fangen_US
dc.contributor.authorNitsche, Michael A.en_US
dc.contributor.departmentDepartment of Neuroscience and Biomedical Engineeringen
dc.contributor.organizationLeibniz Research Centre for Working Environment and Human Factorsen_US
dc.contributor.organizationIlmenau University of Technologyen_US
dc.date.accessioned2023-04-05T06:19:22Z
dc.date.available2023-04-05T06:19:22Z
dc.date.issued2023-03-01en_US
dc.descriptionFunding Information: This work was supported by a research grant from the German Federal Ministry of Education and Research ( BMBF ) (GCBS grant 01EE1501 ). TP Mutanen has been funded by the Academy of Finland, Finland (Grant No. 321631 ). Publisher Copyright: © 2023 The Authors
dc.description.abstractNeurophysiological effects of transcranial direct current stimulation (tDCS) have been extensively studied over the primary motor cortex (M1). Much less is however known about its effects over non-motor areas, such as the prefrontal cortex (PFC), which is the neuronal foundation for many high-level cognitive functions and involved in neuropsychiatric disorders. In this study, we, therefore, explored the transferability of cathodal tDCS effects over M1 to the PFC. Eighteen healthy human participants (11 males and 8 females) were involved in eight randomized sessions per participant, in which four cathodal tDCS dosages, low, medium, and high, as well as sham stimulation, were applied over the left M1 and left PFC. After-effects of tDCS were evaluated via transcranial magnetic stimulation (TMS)-electroencephalography (EEG), and TMS-elicited motor evoked potentials (MEP), for the outcome parameters TMS-evoked potentials (TEP), TMS-evoked oscillations, and MEP amplitude alterations. TEPs were studied both at the regional and global scalp levels. The results indicate a regional dosage-dependent nonlinear neurophysiological effect of M1 tDCS, which is not one-to-one transferable to PFC tDCS. Low and high dosages of M1 tDCS reduced early positive TEP peaks (P30, P60), and MEP amplitudes, while an enhancement was observed for medium dosage M1 tDCS (P30). In contrast, prefrontal low, medium and high dosage tDCS uniformly reduced the early positive TEP peak amplitudes. Furthermore, for both cortical areas, regional tDCS-induced modulatory effects were not observed for late TEP peaks, nor TMS-evoked oscillations. However, at the global scalp level, widespread effects of tDCS were observed for both, TMS-evoked potentials and oscillations. This study provides the first direct physiological comparison of tDCS effects applied over different brain areas and therefore delivers crucial information for future tDCS applications.en
dc.description.versionPeer revieweden
dc.format.extent25
dc.format.extent515-539
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationMosayebi-Samani, M, Agboada, D, Mutanen, T P, Haueisen, J, Kuo, M F & Nitsche, M A 2023, ' Transferability of cathodal tDCS effects from the primary motor to the prefrontal cortex: A multimodal TMS-EEG study ', Brain Stimulation, vol. 16, no. 2, pp. 515-539 . https://doi.org/10.1016/j.brs.2023.02.010en
dc.identifier.doi10.1016/j.brs.2023.02.010en_US
dc.identifier.issn1935-861X
dc.identifier.issn1876-4754
dc.identifier.otherPURE UUID: ba8e5688-c051-4ef0-9e1b-1794863042b4en_US
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/ba8e5688-c051-4ef0-9e1b-1794863042b4en_US
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85148683701&partnerID=8YFLogxKen_US
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/104913323/Transferability_of_cathodal_tDCS_effects_from_the_primary_motor_to_the_prefrontal_cortex.pdfen_US
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/120370
dc.identifier.urnURN:NBN:fi:aalto-202304052688
dc.language.isoenen
dc.publisherElsevier Inc.
dc.relation.ispartofseriesBrain Stimulationen
dc.relation.ispartofseriesVolume 16, issue 2en
dc.rightsopenAccessen
dc.titleTransferability of cathodal tDCS effects from the primary motor to the prefrontal cortex: A multimodal TMS-EEG studyen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion
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