Auditory and Cognitive Deficits Associated with Acquired Amusia after Stroke: A Magnetoencephalography and Neuropsychological Follow-Up Study

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dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorSärkämö, Teppo
dc.contributor.authorTervaniemi, Mari
dc.contributor.authorSoinila, Seppo
dc.contributor.authorAutti, Taina
dc.contributor.authorSilvennoinen, Heli M.
dc.contributor.authorLaine, Matti
dc.contributor.authorHietanen, Marja
dc.contributor.authorPihko, Elina
dc.contributor.departmentDepartment of Neuroscience and Biomedical Engineeringen
dc.date.accessioned2017-05-11T08:37:23Z
dc.date.available2017-05-11T08:37:23Z
dc.date.issued2010
dc.description.abstractAcquired amusia is a common disorder after damage to the middle cerebral artery (MCA) territory. However, its neurocognitive mechanisms, especially the relative contribution of perceptual and cognitive factors, are still unclear. We studied cognitive and auditory processing in the amusic brain by performing neuropsychological testing as well as magnetoencephalography (MEG) measurements of frequency and duration discrimination using magnetic mismatch negativity (MMNm) recordings. Fifty-three patients with a left (n = 24) or right (n = 29) hemisphere MCA stroke (MRI verified) were investigated 1 week, 3 months, and 6 months after the stroke. Amusia was evaluated using the Montreal Battery of Evaluation of Amusia (MBEA). We found that amusia caused by right hemisphere damage (RHD), especially to temporal and frontal areas, was more severe than amusia caused by left hemisphere damage (LHD). Furthermore, the severity of amusia was found to correlate with weaker frequency MMNm responses only in amusic RHD patients.Additionally, within the RHD subgroup, the amusic patients who had damage to the auditory cortex (AC) showed worse recovery on the MBEA as well as weaker MMNm responses throughout the 6-month follow-up than the non-amusic patients or the amusic patients without AC damage. Furthermore, the amusic patients both with and without AC damage performed worse than the non-amusic patients on tests of working memory, attention, and cognitive flexibility. These findings suggest domain-general cognitive deficits to be the primary mechanism underlying amusia without AC damage whereas amusia with AC damage is associated with both auditory and cognitive deficits.en
dc.description.versionPeer revieweden
dc.format.extent1-12
dc.format.mimetypeapplication/pdf
dc.identifier.citationSärkämö , T , Tervaniemi , M , Soinila , S , Autti , T , Silvennoinen , H M , Laine , M , Hietanen , M & Pihko , E 2010 , ' Auditory and Cognitive Deficits Associated with Acquired Amusia after Stroke: A Magnetoencephalography and Neuropsychological Follow-Up Study ' , PloS one , vol. 5 , no. 12 , e15157 , pp. 1-12 . https://doi.org/10.1371/journal.pone.0015157en
dc.identifier.doi10.1371/journal.pone.0015157
dc.identifier.issn1932-6203
dc.identifier.otherPURE UUID: 8bf75733-fb57-4138-8c82-4018c19d5801
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/8bf75733-fb57-4138-8c82-4018c19d5801
dc.identifier.otherPURE LINK: http://www.plosone.org/article/info:doi/10.1371/journal.pone.0015157
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/12870963/journal.pone.0015157.pdf
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/25682
dc.identifier.urnURN:NBN:fi:aalto-201705114066
dc.language.isoenen
dc.relation.ispartofseriesPLOS ONEen
dc.relation.ispartofseriesVolume 5, issue 12en
dc.rightsopenAccessen
dc.subject.keywordAuditory and cognitive deficits
dc.subject.keywordfollow-up study
dc.subject.keywordmagnetic fields
dc.subject.keywordmagnetoencephalography
dc.subject.keywordmagnetoencephalography and neuropsychological
dc.titleAuditory and Cognitive Deficits Associated with Acquired Amusia after Stroke: A Magnetoencephalography and Neuropsychological Follow-Up Studyen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion
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