Functional network connectivity and topology during naturalistic stimulus is altered in first-episode psychosis

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorRikandi, Eva
dc.contributor.authorMäntylä, Teemu
dc.contributor.authorLindgren, Maija
dc.contributor.authorKieseppä, Tuula
dc.contributor.authorSuvisaari, Jaana
dc.contributor.authorRaij, Tuukka T.
dc.contributor.departmentDepartment of Neuroscience and Biomedical Engineering
dc.contributor.departmentNational Institute for Health and Welfare
dc.contributor.departmentUniversity of Helsinki
dc.date.accessioned2022-02-16T07:41:11Z
dc.date.available2022-02-16T07:41:11Z
dc.date.issued2022-03
dc.descriptionFunding Information: This work was supported by the Sigrid Jusélius Foundation (J.S., E.R.), the Finnish Cultural Foundation (J.S. and T.M.), European Union Seventh Framework Programme ( FP7/2007–2013 ), grant agreement no 602478 (J.S.), the Jalmari and Rauha Ahokas Foundation (T.M.), the Doctoral Program Brain and Mind of the University of Helsinki (T.M.), the Yrjö Jahnsson Foundation (# 6781 to M.L.), the Päivikki and Sakari Sohlberg Foundation (M.L.), the Academy of Finland (# 278171 to J.S. and T.T.R.) and the Finnish Medical Foundation (T.T.R.) Funding Information: This work was supported by the Sigrid Jus?lius Foundation (J.S., E.R.), the Finnish Cultural Foundation (J.S. and T.M.), European Union Seventh Framework Programme (FP7/2007?2013), grant agreement no 602478 (J.S.), the Jalmari and Rauha Ahokas Foundation (T.M.), the Doctoral Program Brain and Mind of the University of Helsinki (T.M.), the Yrj? Jahnsson Foundation (#6781 to M.L.), the P?ivikki and Sakari Sohlberg Foundation (M.L.), the Academy of Finland (#278171 to J.S. and T.T.R.) and the Finnish Medical Foundation (T.T.R.) Publisher Copyright: © 2022 The Authors
dc.description.abstractBackground: Psychotic disorders have been suggested to derive from dysfunctional integration of signaling between brain regions. Earlier studies have found several changes in functional network synchronization as well as altered network topology in patients with psychotic disorders. However, studies have used mainly resting-state that makes it more difficult to link functional alterations to any specific stimulus or experience. We set out to examine functional connectivity as well as graph (topological) measures and their association to symptoms in first-episode psychosis patients during movie viewing. Our goal was to understand whole-brain functional dynamics of complex naturalistic information processing in psychosis and changes in brain functional organization related to symptoms. Methods: 71 first-episode psychosis patients and 57 control subjects watched scenes from the movie Alice in Wonderland during 3 T fMRI. We compared functional connectivity and graph measures indicating integration, segregation and centrality between groups, and examined the association between topology and symptom scores in the patient group. Results: We identified a subnetwork with predominantly decreased links of functional connectivity in first-episode psychosis patients. The subnetwork was mainly comprised of nodes of and links between the cingulo-opercular, sensorimotor and default-mode networks. In topological measures, we observed between-group differences in properties of centrality. Conclusions: Functional brain networks are affected during naturalistic information processing already in the early stages of psychosis, concentrated in salience- and cognitive control-related hubs and subnetworks. Understanding these aberrant dynamics could add to better targeted cognitive and behavioral interventions in the early stages of psychotic disorders.en
dc.description.versionPeer revieweden
dc.format.extent9
dc.format.extent83-91
dc.format.mimetypeapplication/pdf
dc.identifier.citationRikandi , E , Mäntylä , T , Lindgren , M , Kieseppä , T , Suvisaari , J & Raij , T T 2022 , ' Functional network connectivity and topology during naturalistic stimulus is altered in first-episode psychosis ' , Schizophrenia Research , vol. 241 , pp. 83-91 . https://doi.org/10.1016/j.schres.2022.01.006en
dc.identifier.doi10.1016/j.schres.2022.01.006
dc.identifier.issn0920-9964
dc.identifier.issn1573-2509
dc.identifier.otherPURE UUID: c8334bed-277d-4c6b-92ab-e1afec3f2c70
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/c8334bed-277d-4c6b-92ab-e1afec3f2c70
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85123678990&partnerID=8YFLogxK
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/79410795/Functional_network_connectivity_and_topology_during_naturalistic_stimulus_is_altered_in_first_episode_psychosis.pdf
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/113051
dc.identifier.urnURN:NBN:fi:aalto-202202161943
dc.language.isoenen
dc.publisherElsevier
dc.relation.ispartofseriesSchizophrenia Researchen
dc.relation.ispartofseriesVolume 241en
dc.rightsopenAccessen
dc.subject.keywordfMRI
dc.subject.keywordFunctional connectivity
dc.subject.keywordNaturalistic stimulus
dc.subject.keywordNetworks
dc.subject.keywordPsychosis
dc.titleFunctional network connectivity and topology during naturalistic stimulus is altered in first-episode psychosisen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion
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