Estrogen Receptor-α Targeting: PROTACs, SNIPERs, Peptide-PROTACs, Antibody Conjugated PROTACs and SNIPERs
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Journal Title
Journal ISSN
Volume Title
A2 Katsausartikkeli tieteellisessä aikakauslehdessä
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Date
2022-11
Major/Subject
Mcode
Degree programme
Language
en
Pages
43
1-43
1-43
Series
PHARMACEUTICS, Volume 14, issue 11
Abstract
Targeting selective estrogen subtype receptors through typical medicinal chemistry approaches is based on occupancy-driven pharmacology. In occupancy-driven pharmacology, molecules are developed in order to inhibit the protein of interest (POI), and their popularity is based on their virtue of faster kinetics. However, such approaches have intrinsic flaws, such as pico-to-nanomolar range binding affinity and continuous dosage after a time interval for sustained inhibition of POI. These shortcomings were addressed by event-driven pharmacology-based approaches, which degrade the POI rather than inhibit it. One such example is PROTACs (Proteolysis targeting chimeras), which has become one of the highly successful strategies of event-driven pharmacology (pharmacology that does the degradation of POI and diminishes its functions). The selective targeting of estrogen receptor subtypes is always challenging for chemical biologists and medicinal chemists. Specifically, estrogen receptor α (ER-α) is expressed in nearly 70% of breast cancer and commonly overexpressed in ovarian, prostate, colon, and endometrial cancer. Therefore, conventional hormonal therapies are most prescribed to patients with ER + cancers. However, on prolonged use, resistance commonly developed against these therapies, which led to selective estrogen receptor degrader (SERD) becoming the first-line drug for metastatic ER + breast cancer. The SERD success shows that removing cellular ER-α is a promising approach to overcoming endocrine resistance. Depending on the mechanism of degradation of ER-α, various types of strategies of developed.Description
Keywords
peptide PROTACs, SNIPERs, PORTACs, antibody-based PROTAC conjugate, clinical PROTACs, GROWTH-FACTOR-I, NF-KAPPA-B, PROSTATE-CANCER PROGRESSION, PROTEIN-PROTEIN INTERACTION, ACTIVATING ESR1 MUTATIONS, BETA-AGONISTS SERBAS, ER-ALPHA, SMALL MOLECULES, BINDING DOMAIN, BREAST-CANCER
Citation
Negi , A , Kesari , K K & Voisin-Chiret , A S 2022 , ' Estrogen Receptor-α Targeting: PROTACs, SNIPERs, Peptide-PROTACs, Antibody Conjugated PROTACs and SNIPERs ' , PHARMACEUTICS , vol. 14 , no. 11 , 2523 , pp. 1-43 . https://doi.org/10.3390/pharmaceutics14112523
