Environmental factors-induced oxidative stress

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorRoychoudhury, Shubhadeep
dc.contributor.authorChakraborty, Saptaparna
dc.contributor.authorChoudhury, Arun Paul
dc.contributor.authorDas, Anandan
dc.contributor.authorJha, Niraj Kumar
dc.contributor.authorSlama, Petr
dc.contributor.authorNath, Monika
dc.contributor.authorMassanyi, Peter
dc.contributor.authorRuokolainen, Janne
dc.contributor.authorKesari, Kavindra Kumar
dc.contributor.departmentAssam University
dc.contributor.departmentSharda University
dc.contributor.departmentMendel University in Brno
dc.contributor.departmentSlovak University of Agriculture in Nitra
dc.contributor.departmentDepartment of Applied Physics
dc.date.accessioned2021-06-09T06:56:47Z
dc.date.available2021-06-09T06:56:47Z
dc.date.issued2021-06
dc.descriptionPublisher Copyright: © 2021 by the authors. Licensee MDPI, Basel, Switzerland. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.
dc.description.abstractHypogonadism is an endocrine disorder characterized by inadequate serum testosterone production by the Leydig cells of the testis. It is triggered by alterations in the hypothalamic–pituitary– gonadal axis. Erectile dysfunction (ED) is another common disorder in men that involves an alteration in erectile response–organic, relational, or psychological. The incidence of hypogonadism and ED is common in men aged over 40 years. Hypogonadism (including late-onset hypogonadism) and ED may be linked to several environmental factors-induced oxidative stresses. The factors mainly include exposure to pesticides, radiation, air pollution, heavy metals and other endocrine-disrupting chemicals. These environmental risk factors may induce oxidative stress and lead to hormonal dysfunctions. To better understand the subject, the study used many keywords, including “hy-pogonadism”, “late-onset hypogonadism”, “testosterone”, “erectile dysfunction”, “reactive oxygen species”, “oxidative stress”, and “environmental pollution” in major online databases, such as SCO-PUS and PUBMED to extract relevant scientific information. Based on these parameters, this review summarizes a comprehensive insight into the important environmental issues that may have a direct or indirect association with hypogonadism and ED in men. The study concludes that environmental factors-induced oxidative stress may cause infertility in men. The hypothesis and outcomes were reviewed critically, and the mechanistic approaches are applied through oxidant-sensitive path-ways. This study also provides reccomendations on future therapeutic interventions and protective measures against such adverse environmental factors-induced hypogonadism and ED.en
dc.description.versionPeer revieweden
dc.format.extent39
dc.format.mimetypeapplication/pdf
dc.identifier.citationRoychoudhury , S , Chakraborty , S , Choudhury , A P , Das , A , Jha , N K , Slama , P , Nath , M , Massanyi , P , Ruokolainen , J & Kesari , K K 2021 , ' Environmental factors-induced oxidative stress : Hormonal and molecular pathway disruptions in hypogonadism and erectile dysfunction ' , Antioxidants , vol. 10 , no. 6 , 837 . https://doi.org/10.3390/antiox10060837en
dc.identifier.doi10.3390/antiox10060837
dc.identifier.issn2076-3921
dc.identifier.otherPURE UUID: db60966d-3785-4b61-a9af-5c3ef74a386f
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/db60966d-3785-4b61-a9af-5c3ef74a386f
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85106253180&partnerID=8YFLogxK
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/63806451/Environmental_Factors_Induced_Oxidative_Stress.antioxidants_10_00837_v2_2.pdf
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/108047
dc.identifier.urnURN:NBN:fi:aalto-202106097305
dc.language.isoenen
dc.publisherMDPI AG
dc.relation.ispartofseriesAntioxidantsen
dc.relation.ispartofseriesVolume 10, issue 6en
dc.rightsopenAccessen
dc.subject.keywordAir pollution
dc.subject.keywordEndocrine-disrupting chemicals
dc.subject.keywordErectile dysfunction
dc.subject.keywordHeavy metals
dc.subject.keywordHypogonadism
dc.subject.keywordInfertility
dc.subject.keywordPesticide
dc.subject.keywordRadiation
dc.subject.keywordTestosterone
dc.titleEnvironmental factors-induced oxidative stressen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion
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