Trends and burden of diabetes in patients with atrial fibrillation during 2007–2018 : A Finnish nationwide cohort study

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorTeppo, Konsta
dc.contributor.authorKouki, Elis
dc.contributor.authorSalmela, Birgitta
dc.contributor.authorNiskanen, Leo
dc.contributor.authorJaakkola, Jussi
dc.contributor.authorHalminen, Olli
dc.contributor.authorHaukka, Jari
dc.contributor.authorPutaala, Jukka
dc.contributor.authorLinna, Miika
dc.contributor.authorMustonen, Pirjo
dc.contributor.authorHartikainen, Juha
dc.contributor.authorJuhani Airaksinen, K. E.
dc.contributor.authorLehto, Mika
dc.contributor.departmentTurku University Hospital
dc.contributor.departmentUniversity of Helsinki
dc.contributor.departmentPäijät-Häme Central Hospital
dc.contributor.departmentDepartment of Industrial Engineering and Management
dc.contributor.departmentUniversity of Eastern Finland
dc.contributor.departmentJorvi Hospital
dc.date.accessioned2023-08-30T04:22:03Z
dc.date.available2023-08-30T04:22:03Z
dc.date.issued2023-09
dc.descriptionFunding Information: This work was supported by the Aarne Koskelo Foundation, The Finnish Foundation for Cardiovascular Research, and Helsinki and Uusimaa Hospital District research fund (TYH2019309). Publisher Copyright: © 2023 The Author(s)
dc.description.abstractAims: We assessed the temporal trends in the prevalence of diabetes and in its associations with outcomes among patients with atrial fibrillation (AF). Methods: The registry-based FinACAF study covered all patients with incident AF in Finland between 2007 and 2018. Ischemic stroke (IS) and mortality rates were computed using Poisson regression model. Results: We identified 229 565 patients (50.0% female; mean age 72.7 years; mean follow-up 4.0 years) patients with incident AF. The prevalence of diabetes increased steadily from 15.5% in 2007 to 26.3% in 2018. A decrease in IS and mortality rates was observed during the study period both in patients with and without diabetes. Diabetes was associated with IS and mortality (adjusted incidence rate ratios with 95% confidence intervals 1.22 (1.17–1.26) and 1.32 (1.29–1.34), respectively). The impact of diabetes on IS risk remained stable, while its effect on mortality increased slightly during the observation period. Conclusions: The prevalence of diabetes has increased considerably among patients with AF between 2007 and 2018. There have been substantial improvements in the prognosis of AF patients with diabetes. However, diabetes remains a significant risk factor for IS and mortality in this patient population.en
dc.description.versionPeer revieweden
dc.format.extent7
dc.format.extent1-7
dc.format.mimetypeapplication/pdf
dc.identifier.citationTeppo , K , Kouki , E , Salmela , B , Niskanen , L , Jaakkola , J , Halminen , O , Haukka , J , Putaala , J , Linna , M , Mustonen , P , Hartikainen , J , Juhani Airaksinen , K E & Lehto , M 2023 , ' Trends and burden of diabetes in patients with atrial fibrillation during 2007–2018 : A Finnish nationwide cohort study ' , Diabetes Research and Clinical Practice , vol. 203 , 110875 , pp. 1-7 . https://doi.org/10.1016/j.diabres.2023.110875en
dc.identifier.doi10.1016/j.diabres.2023.110875
dc.identifier.issn0168-8227
dc.identifier.otherPURE UUID: c5ef98e1-19c5-44ce-8e3a-9381d6567be0
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/c5ef98e1-19c5-44ce-8e3a-9381d6567be0
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85167987284&partnerID=8YFLogxK
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/119390103/Trends_and_burden_of_diabetes_in_patients_with_atrial_fibrillation_during_2007_2018.pdf
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/123002
dc.identifier.urnURN:NBN:fi:aalto-202308305342
dc.language.isoenen
dc.publisherElsevier Ireland Ltd
dc.relation.ispartofseriesDIABETES RESEARCH AND CLINICAL PRACTICEen
dc.relation.ispartofseriesVolume 203en
dc.rightsopenAccessen
dc.subject.keywordAtrial fibrillation
dc.subject.keywordDiabetes
dc.subject.keywordIschemic stroke
dc.subject.keywordMortality
dc.subject.keywordPrevalence
dc.subject.keywordPrognosis
dc.subject.keywordTrends
dc.titleTrends and burden of diabetes in patients with atrial fibrillation during 2007–2018 : A Finnish nationwide cohort studyen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion
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