Trends and burden of diabetes in patients with atrial fibrillation during 2007–2018 : A Finnish nationwide cohort study

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorTeppo, Konstaen_US
dc.contributor.authorKouki, Elisen_US
dc.contributor.authorSalmela, Birgittaen_US
dc.contributor.authorNiskanen, Leoen_US
dc.contributor.authorJaakkola, Jussien_US
dc.contributor.authorHalminen, Ollien_US
dc.contributor.authorHaukka, Jarien_US
dc.contributor.authorPutaala, Jukkaen_US
dc.contributor.authorLinna, Miikaen_US
dc.contributor.authorMustonen, Pirjoen_US
dc.contributor.authorHartikainen, Juhaen_US
dc.contributor.authorJuhani Airaksinen, K. E.en_US
dc.contributor.authorLehto, Mikaen_US
dc.contributor.departmentDepartment of Industrial Engineering and Managementen
dc.contributor.organizationTurku University Hospitalen_US
dc.contributor.organizationUniversity of Helsinkien_US
dc.contributor.organizationPäijät-Häme Central Hospitalen_US
dc.contributor.organizationUniversity of Eastern Finlanden_US
dc.contributor.organizationJorvi Hospitalen_US
dc.date.accessioned2023-08-30T04:22:03Z
dc.date.available2023-08-30T04:22:03Z
dc.date.issued2023-09en_US
dc.descriptionFunding Information: This work was supported by the Aarne Koskelo Foundation, The Finnish Foundation for Cardiovascular Research, and Helsinki and Uusimaa Hospital District research fund (TYH2019309). Publisher Copyright: © 2023 The Author(s)
dc.description.abstractAims: We assessed the temporal trends in the prevalence of diabetes and in its associations with outcomes among patients with atrial fibrillation (AF). Methods: The registry-based FinACAF study covered all patients with incident AF in Finland between 2007 and 2018. Ischemic stroke (IS) and mortality rates were computed using Poisson regression model. Results: We identified 229 565 patients (50.0% female; mean age 72.7 years; mean follow-up 4.0 years) patients with incident AF. The prevalence of diabetes increased steadily from 15.5% in 2007 to 26.3% in 2018. A decrease in IS and mortality rates was observed during the study period both in patients with and without diabetes. Diabetes was associated with IS and mortality (adjusted incidence rate ratios with 95% confidence intervals 1.22 (1.17–1.26) and 1.32 (1.29–1.34), respectively). The impact of diabetes on IS risk remained stable, while its effect on mortality increased slightly during the observation period. Conclusions: The prevalence of diabetes has increased considerably among patients with AF between 2007 and 2018. There have been substantial improvements in the prognosis of AF patients with diabetes. However, diabetes remains a significant risk factor for IS and mortality in this patient population.en
dc.description.versionPeer revieweden
dc.format.extent7
dc.format.extent1-7
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationTeppo, K, Kouki, E, Salmela, B, Niskanen, L, Jaakkola, J, Halminen, O, Haukka, J, Putaala, J, Linna, M, Mustonen, P, Hartikainen, J, Juhani Airaksinen, K E & Lehto, M 2023, ' Trends and burden of diabetes in patients with atrial fibrillation during 2007–2018 : A Finnish nationwide cohort study ', Diabetes Research and Clinical Practice, vol. 203, 110875, pp. 1-7 . https://doi.org/10.1016/j.diabres.2023.110875en
dc.identifier.doi10.1016/j.diabres.2023.110875en_US
dc.identifier.issn0168-8227
dc.identifier.otherPURE UUID: c5ef98e1-19c5-44ce-8e3a-9381d6567be0en_US
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/c5ef98e1-19c5-44ce-8e3a-9381d6567be0en_US
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85167987284&partnerID=8YFLogxKen_US
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/119390103/Trends_and_burden_of_diabetes_in_patients_with_atrial_fibrillation_during_2007_2018.pdfen_US
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/123002
dc.identifier.urnURN:NBN:fi:aalto-202308305342
dc.language.isoenen
dc.publisherElsevier Ireland Ltd
dc.relation.ispartofseriesDIABETES RESEARCH AND CLINICAL PRACTICEen
dc.relation.ispartofseriesVolume 203en
dc.rightsopenAccessen
dc.subject.keywordAtrial fibrillationen_US
dc.subject.keywordDiabetesen_US
dc.subject.keywordIschemic strokeen_US
dc.subject.keywordMortalityen_US
dc.subject.keywordPrevalenceen_US
dc.subject.keywordPrognosisen_US
dc.subject.keywordTrendsen_US
dc.titleTrends and burden of diabetes in patients with atrial fibrillation during 2007–2018 : A Finnish nationwide cohort studyen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion

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