The Reaction Mechanism of Spirocylization and Stereoselectivity Studies for the Calyculin C16-C25 Fragment

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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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Date
2005
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Language
en
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European Journal of Organic Chemistry
Abstract
The mechanism of the double intramolecular hetero-Michael addition, a key reaction in the planned synthesis of the natural product calyculin C, has been studied by NMR. The cyclization follows Baldwin’s rules and proceeds first through a six-membered ring closure (6-endo-dig), followed by a fivemembered ring cyclization (5-exo-trig).
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Keywords
cyclization, Michael addition
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Citation
Koskinen , A M P , Rauhala , V , Nättinen , K & Rissanen , K 2005 , ' The Reaction Mechanism of Spirocylization and Stereoselectivity Studies for the Calyculin C16-C25 Fragment ' , European Journal of Organic Chemistry . https://doi.org/10.1002/ejoc.200500206