Real-Time Raman Monitoring of Calcium Phosphate Precipitation in a Semi-Batch Stirred Crystallizer

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Journal Title
Journal ISSN
Volume Title
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Date
2018-03-07
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Mcode
Degree programme
Language
en
Pages
7
1622-1628
Series
Crystal Growth and Design, Volume 18, issue 3
Abstract
Semi-batch precipitation of calcium monohydrogen phosphate dihydrate (CaHPO4·2H2O; also termed dicalcium phosphate dihydrate, DCPD) from a homogeneous reaction of KH2PO4 and CaCl2 was studied with inline Raman spectroscopy. In the reaction, hydroxyapatite (HAP, Ca5OH(PO4)3) formed first and transferred to DCPD throughout the entire precipitation process. Raman calibration models were created with a series of KH2PO4-NaOH-water solutions. The reliability of the calibration models was validated with offline measurement of phosphate concentration in the mother liquor. Real-time changes in HPO4 2- and H2PO4 - concentration were monitored and predicted. Comprehensive kinetic information was obtained from liquid and solid analysis. It was found that the influence of the mixing rate on the precipitation was not significant, whereas the reactant feeding rate had a remarkable impact.
Description
TARKISTA ONKO TÄMÄ AVATTU 2019.
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Citation
Han , B & Louhi-Kultanen , M 2018 , ' Real-Time Raman Monitoring of Calcium Phosphate Precipitation in a Semi-Batch Stirred Crystallizer ' , Crystal Growth and Design , vol. 18 , no. 3 , pp. 1622-1628 . https://doi.org/10.1021/acs.cgd.7b01587