Albumin Stabilized Fe@C Core–Shell Nanoparticles as Candidates for Magnetic Hyperthermia Therapy
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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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en
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9
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Nanomaterials, Volume 12, issue 16
Abstract
Carbon-encapsulated iron nanoparticles (Fe@C) with a mean diameter of 15 nm have been synthesized using evaporation–condensation flow–levitation method by the direct iron-carbon gas-phase reaction at high temperatures. Further, Fe@C were stabilized with bovine serum albumin (BSA) coating, and their electromagnetic properties were evaluated to test their performance in magnetic hyperthermia therapy (MHT) through a specific absorption rate (SAR). Heat generation was observed at different Fe@C concentrations (1, 2.5, and 5 mg/mL) when applied 331 kHz and 60 kA/m of an alternating magnetic field, resulting in SAR values of 437.64, 129.36, and 50.4 W/g for each concentration, respectively. Having such high SAR values at low concentrations, obtained material is ideal for use in MHT.Description
Publisher Copyright: © 2022 by the authors.
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Ramírez-Morales, M A, Goldt, A E, Kalachikova, P M, Ramirez B, J A, Suzuki, M, Zhigach, A N, Ben Salah, A, Shurygina, L I, Shandakov, S D, Zatsepin, T, Krasnikov, D V, Maekawa, T, Nikolaev, E N & Nasibulin, A G 2022, 'Albumin Stabilized Fe@C Core–Shell Nanoparticles as Candidates for Magnetic Hyperthermia Therapy', Nanomaterials, vol. 12, no. 16, 2869. https://doi.org/10.3390/nano12162869