Albumin Stabilized Fe@C Core–Shell Nanoparticles as Candidates for Magnetic Hyperthermia Therapy

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Journal Title
Journal ISSN
Volume Title
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Date
2022-08
Major/Subject
Mcode
Degree programme
Language
en
Pages
Series
Nanomaterials, Volume 12, issue 16
Abstract
Carbon-encapsulated iron nanoparticles (Fe@C) with a mean diameter of 15 nm have been synthesized using evaporation–condensation flow–levitation method by the direct iron-carbon gas-phase reaction at high temperatures. Further, Fe@C were stabilized with bovine serum albumin (BSA) coating, and their electromagnetic properties were evaluated to test their performance in magnetic hyperthermia therapy (MHT) through a specific absorption rate (SAR). Heat generation was observed at different Fe@C concentrations (1, 2.5, and 5 mg/mL) when applied 331 kHz and 60 kA/m of an alternating magnetic field, resulting in SAR values of 437.64, 129.36, and 50.4 W/g for each concentration, respectively. Having such high SAR values at low concentrations, obtained material is ideal for use in MHT.
Description
Publisher Copyright: © 2022 by the authors.
Keywords
core–shell nanoparticles, ferromagnetic particles, flow-levitation method, iron nanoparticles, magnetic hyperthermia
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Citation
Ramírez-Morales , M A , Goldt , A E , Kalachikova , P M , Ramirez B , J A , Suzuki , M , Zhigach , A N , Ben Salah , A , Shurygina , L I , Shandakov , S D , Zatsepin , T , Krasnikov , D V , Maekawa , T , Nikolaev , E N & Nasibulin , A G 2022 , ' Albumin Stabilized Fe@C Core–Shell Nanoparticles as Candidates for Magnetic Hyperthermia Therapy ' , Nanomaterials , vol. 12 , no. 16 , 2869 . https://doi.org/10.3390/nano12162869