Synthesis and agonist properties of novel quinoline and isoquinoline derivatives toward the cannabinoid receptor CB2

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorReux, Bastien
dc.contributor.authorNevalainen, Tapio
dc.contributor.authorRaitio, Katri H.
dc.contributor.authorKoskinen, Ari M.P.
dc.contributor.departmentDepartment of Chemistryen
dc.date.accessioned2016-09-23T08:16:45Z
dc.date.issued2009
dc.description.abstractA series of quinolinyl and isoquinolinyl phenyl ketones was synthesized and their CB2 receptor-dependent G-protein activities were determined using the [35S]GTPcS binding assay. Both quinoline and isoquinoline derivatives exhibited similar CB2 receptor agonist activity, the most potent ligands being the 2-(Me2N)-phenyl substituted derivatives, which were also full agonists at the CB2-receptor.en
dc.description.versionPeer revieweden
dc.format.extent4441-4447
dc.format.mimetypeapplication/pdf
dc.identifier.citationReux , B , Nevalainen , T , Raitio , K H & Koskinen , A M P 2009 , ' Synthesis and agonist properties of novel quinoline and isoquinoline derivatives toward the cannabinoid receptor CB2 ' , Bioorganic and Medicinal Chemistry , vol. 17 , no. 13 , pp. 4441-4447 . https://doi.org/10.1016/j.bmc.2009.05.013en
dc.identifier.doi10.1016/j.bmc.2009.05.013
dc.identifier.issn0968-0896
dc.identifier.otherPURE UUID: 89154ef5-74e4-4337-877e-5d85d3db2d4d
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/89154ef5-74e4-4337-877e-5d85d3db2d4d
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/7159814/ms141.pdf
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/22322
dc.identifier.urnURN:NBN:fi:aalto-201609234326
dc.language.isoenen
dc.relation.ispartofseriesBIOORGANIC AND MEDICINAL CHEMISTRYen
dc.relation.ispartofseriesVolume 17, issue 13en
dc.rightsopenAccessen
dc.subject.keywordcannabinoid
dc.subject.keywordreceptor CB2
dc.subject.keywordquinoline
dc.subject.keywordisoquinoline
dc.titleSynthesis and agonist properties of novel quinoline and isoquinoline derivatives toward the cannabinoid receptor CB2en
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionacceptedVersion
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