Synthesis and agonist properties of novel quinoline and isoquinoline derivatives toward the cannabinoid receptor CB2

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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

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en

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Bioorganic and Medicinal Chemistry, Volume 17, issue 13, pp. 4441-4447

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A series of quinolinyl and isoquinolinyl phenyl ketones was synthesized and their CB2 receptor-dependent G-protein activities were determined using the [35S]GTPcS binding assay. Both quinoline and isoquinoline derivatives exhibited similar CB2 receptor agonist activity, the most potent ligands being the 2-(Me2N)-phenyl substituted derivatives, which were also full agonists at the CB2-receptor.

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Reux, B, Nevalainen, T, Raitio, K H & Koskinen, A M P 2009, 'Synthesis and agonist properties of novel quinoline and isoquinoline derivatives toward the cannabinoid receptor CB2', Bioorganic and Medicinal Chemistry, vol. 17, no. 13, pp. 4441-4447. https://doi.org/10.1016/j.bmc.2009.05.013