Synthesis and agonist properties of novel quinoline and isoquinoline derivatives toward the cannabinoid receptor CB2
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
BIOORGANIC AND MEDICINAL CHEMISTRY, Volume 17, issue 13
AbstractA series of quinolinyl and isoquinolinyl phenyl ketones was synthesized and their CB2 receptor-dependent G-protein activities were determined using the [35S]GTPcS binding assay. Both quinoline and isoquinoline derivatives exhibited similar CB2 receptor agonist activity, the most potent ligands being the 2-(Me2N)-phenyl substituted derivatives, which were also full agonists at the CB2-receptor.
cannabinoid, receptor CB2, quinoline, isoquinoline
Reux , B , Nevalainen , T , Raitio , K H & Koskinen , A M P 2009 , ' Synthesis and agonist properties of novel quinoline and isoquinoline derivatives toward the cannabinoid receptor CB2 ' , Bioorganic and Medicinal Chemistry , vol. 17 , no. 13 , pp. 4441-4447 . https://doi.org/10.1016/j.bmc.2009.05.013