Synthesis and agonist properties of novel quinoline and isoquinoline derivatives toward the cannabinoid receptor CB2

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Volume Title
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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Date
2009
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Mcode
Degree programme
Language
en
Pages
4441-4447
Series
BIOORGANIC AND MEDICINAL CHEMISTRY, Volume 17, issue 13
Abstract
A series of quinolinyl and isoquinolinyl phenyl ketones was synthesized and their CB2 receptor-dependent G-protein activities were determined using the [35S]GTPcS binding assay. Both quinoline and isoquinoline derivatives exhibited similar CB2 receptor agonist activity, the most potent ligands being the 2-(Me2N)-phenyl substituted derivatives, which were also full agonists at the CB2-receptor.
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Keywords
cannabinoid, receptor CB2, quinoline, isoquinoline
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Citation
Reux , B , Nevalainen , T , Raitio , K H & Koskinen , A M P 2009 , ' Synthesis and agonist properties of novel quinoline and isoquinoline derivatives toward the cannabinoid receptor CB2 ' , Bioorganic and Medicinal Chemistry , vol. 17 , no. 13 , pp. 4441-4447 . https://doi.org/10.1016/j.bmc.2009.05.013