Synthesis and agonist properties of novel quinoline and isoquinoline derivatives toward the cannabinoid receptor CB2

A series of quinolinyl and isoquinolinyl phenyl ketones was synthesized and their CB2 receptor-dependent G-protein activities were determined using the [35S]GTPcS binding assay. Both quinoline and isoquinoline derivatives exhibited similar CB2 receptor agonist activity, the most potent ligands being the 2-(Me2N)-phenyl substituted derivatives, which were also full agonists at the CB2-receptor.

Keywords

cannabinoid, receptor CB2, quinoline, isoquinoline

DOI

10.1016/j.bmc.2009.05.013

Citation

Reux , B , Nevalainen , T , Raitio , K H & Koskinen , A M P 2009 , ' Synthesis and agonist properties of novel quinoline and isoquinoline derivatives toward the cannabinoid receptor CB2 ' , Bioorganic and Medicinal Chemistry , vol. 17 , no. 13 , pp. 4441-4447 . https://doi.org/10.1016/j.bmc.2009.05.013

Permanent link to this item

https://urn.fi/URN:NBN:fi:aalto-201609234326

Collections

[article-cris] Kemian tekniikan korkeakoulu / CHEM

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