State-like changes in the salience network correlate with delusion severity in first-episode psychosis patients
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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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Date
2022
Major/Subject
Mcode
Degree programme
Language
en
Pages
10
1-10
1-10
Series
NeuroImage: Clinical, Volume 36
Abstract
Background and hypothesis: Delusions are characteristic of psychotic disorders; however, the brain correlates of delusions remain poorly known. Imaging studies on delusions typically compare images across individuals. Related confounding of inter-individual differences beyond delusions may be avoided by comparing delusional and non-delusional states within individuals. Study design: We studied correlations of delusions using intra-subject correlation (intra-SC) and inter-subject correlation of functional magnetic resonance imaging (fMRI) signal time series, obtained during a movie stimulus at baseline and follow-up. We included 27 control subjects and 24 first-episode psychosis patients, who were free of delusions at follow-up, to calculate intra-SC between fMRI signals obtained during the two time points. In addition, we studied changes in functional connectivity at baseline and during the one-year follow-up using regions where delusion severity correlated with intra-SC as seeds. Results: The intra-SC correlated negatively with the baseline delusion severity in the bilateral anterior insula. In addition, we observed a subthreshold cluster in the anterior cingulate. These three regions constitute the cortical salience network (SN). Functional connectivity between the bilateral insula and the precuneus was weaker in the patients at baseline than in patients at follow-up or in control subjects at any time point. Conclusions: The results suggest that intra-SC is a powerful tool to study brain correlates of symptoms and highlight the role of the SN and internetwork dysconnectivity between the SN and the default mode network in delusions.Description
Funding Information: This work was supported by the Sigrid Jusélius Foundation (J.S.), the Finnish Cultural Foundation (J.S.), the Medical Society of Finland (J.M.P.), the Academy of Finland (grants #278171 and #323035 to J.S. and #315861 to T.T.R.), the Finnish Medical Foundation (J.M.P. and T.T.R.), state funding for university-level health research (Hospital District of Helsinki and Uusimaa #TYH2013332, #TYH2014228, #TYH2017128 to T.K.), and the European Union's Seventh Framework Programme for project METSY (# 602478 to J.S.). The Helsinki Early Psychosis Study is a collaborative work between the Finnish Institute for Health and Welfare, VTT Technical Research Centre of Finland, University Hospital District of Helsinki and Uusimaa, and Aalto University. We thank all the participants in the study. In addition, for their work on the Helsinki Early Psychosis Study, we thank Eva Rikandi, Marita Kattelus, Tuula Mononen, Laura Hietikka, Sanna Leppänen, Teemu Mäntylä and Marjut Grainger. Finally, we thank the peer reviewers for insightful comments and questions that greatly contributed to the final version of this manuscript. Publisher Copyright: © 2022
Keywords
Delusions, First-episode psychosis, fMRI, Intra-subject correlation
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Citation
Panula , J M , Alho , J , Lindgren , M , Kieseppä , T , Suvisaari , J & Raij , T T 2022 , ' State-like changes in the salience network correlate with delusion severity in first-episode psychosis patients ' , NeuroImage: Clinical , vol. 36 , 103234 , pp. 1-10 . https://doi.org/10.1016/j.nicl.2022.103234
