Magnetic resonance-only simulation and dose calculation in external beam radiation therapy: a feasibility study for pelvic cancers

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorKemppainen, Rekoen_US
dc.contributor.authorSuilamo, Samien_US
dc.contributor.authorTuokkola, Terhien_US
dc.contributor.authorLindholm, Paulaen_US
dc.contributor.authorDeppe, Martin H.en_US
dc.contributor.authorKeyriläinen, Janien_US
dc.contributor.departmentDepartment of Neuroscience and Biomedical Engineeringen
dc.contributor.organizationPhilips MR Therapyen_US
dc.contributor.organizationUniversity of Turkuen_US
dc.date.accessioned2020-03-13T15:25:24Z
dc.date.available2020-03-13T15:25:24Z
dc.date.issued2017-05-04en_US
dc.description.abstractBackground: The clinical feasibility of using pseudo-computed tomography (pCT) images derived from magnetic resonance (MR) images for external bean radiation therapy (EBRT) planning for prostate cancer patients has been well demonstrated. This paper investigates the feasibility of applying an MR-derived, pCT planning approach to additional types of cancer in the pelvis. Material and methods: Fifteen patients (five prostate cancer patients, five rectal cancer patients, and five gynecological cancer patients) receiving EBRT at Turku University Hospital (Turku, Finland) were included in the study. Images from an MRCAT (Magnetic Resonance for Calculating ATtenuation, Philips, Vantaa, Finland) pCT method were generated as a part of a clinical MR-simulation procedure. Dose calculation accuracy was assessed by comparing the pCT-based calculation with a CT-based calculation. In addition, the degree of geometric accuracy was studied. Results: The median relative difference of PTV mean dose between CT and pCT images was within 0.8% for all tumor types. When assessing the tumor site-specific accuracy, the median [range] relative dose differences to the PTV mean were 0.7 [−0.11;1.05]% for the prostate cases, 0.3 [−0.25;0.57]% for the rectal cases, and 0.09 [−0.69;0.25]% for the gynecological cancer cases. System-induced geometric distortion was measured to be less than 1 mm for all PTV volumes and the effect on the PTV median dose was less than 0.1%. Conclusions: According to the comparison, using pCT for clinical EBRT planning and dose calculation in the three investigated types of pelvic cancers is feasible. Further studies are required to demonstrate the applicability to a larger cohort of patients.en
dc.description.versionPeer revieweden
dc.format.extent7
dc.format.extent792-798
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationKemppainen, R, Suilamo, S, Tuokkola, T, Lindholm, P, Deppe, M H & Keyriläinen, J 2017, ' Magnetic resonance-only simulation and dose calculation in external beam radiation therapy : a feasibility study for pelvic cancers ', Acta Oncologica, vol. 56, no. 6, pp. 792-798 . https://doi.org/10.1080/0284186X.2017.1293290en
dc.identifier.doi10.1080/0284186X.2017.1293290en_US
dc.identifier.issn0284-186X
dc.identifier.otherPURE UUID: b13ac115-7c4d-41eb-8be4-6ab365477924en_US
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/b13ac115-7c4d-41eb-8be4-6ab365477924en_US
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85014718031&partnerID=8YFLogxKen_US
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/41493260/SCI_Magnetic_Resonance_Only_Simulation.pub1_Author_submitted_manuscript.pdfen_US
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/43455
dc.identifier.urnURN:NBN:fi:aalto-202003132496
dc.language.isoenen
dc.publisherTAYLOR & FRANCIS
dc.relation.ispartofseriesActa Oncologicaen
dc.relation.ispartofseriesVolume 56, issue 6en
dc.rightsopenAccessen
dc.titleMagnetic resonance-only simulation and dose calculation in external beam radiation therapy: a feasibility study for pelvic cancersen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionacceptedVersion

Files