Assessment of dosimetric and positioning accuracy of a magnetic resonance imaging-only solution for external beam radiotherapy of pelvic anatomy

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorKemppainen, Rekoen_US
dc.contributor.authorSuilamo, Samien_US
dc.contributor.authorRanta, Iiroen_US
dc.contributor.authorPesola, Markoen_US
dc.contributor.authorHalkola, Aleksien_US
dc.contributor.authorEufemio, Alvinen_US
dc.contributor.authorMinn, Heikkien_US
dc.contributor.authorKeyriläinen, Janien_US
dc.contributor.departmentDepartment of Neuroscience and Biomedical Engineeringen
dc.contributor.organizationUniversity of Turkuen_US
dc.contributor.organizationAltria Groupen_US
dc.date.accessioned2019-09-03T13:43:15Z
dc.date.available2019-09-03T13:43:15Z
dc.date.issued2019-07-01en_US
dc.description.abstractBackground and purpose: The clinical feasibility of synthetic computed tomography (sCT) images derived from magnetic resonance imaging (MRI) images for external beam radiation therapy (EBRT) planning have been studied and adopted into clinical use recently. This paper evaluates the dosimetric and positioning performance of a sCT approach for different pelvic cancers. Materials and methods: Seventy-five patients receiving EBRT at Turku University Hospital (Turku, Finland) were enrolled in the study. The sCT images were generated as part of a clinical MRI-simulation procedure. Dose calculation accuracy was assessed by comparing the sCT-based calculation with a CT-based calculation. In addition, we evaluated the patient position verification accuracy for both digitally reconstructed radiograph (DRR) and cone beam computed tomography (CBCT) -based image guidance using a subset of the cohort. Furthermore, the relevance of using continuous Hounsfield unit values was assessed. Results: The mean (standard deviation) relative dose difference in the planning target volume mean dose computed over various cancer groups was less than 0.2 (0.4)% between sCT and CT. Among all groups, the average minimum gamma-index pass-rates were better than 95% with a 2%/2mm gamma-criteria. The difference between sCT- and CT-DRR-based patient positioning was less than 0.3 (1.4) mm in all directions. The registrations of sCT to CBCT produced similar results as compared with CT to CBCT registrations. Conclusions: The use of sCT for clinical EBRT dose calculation and patient positioning in the investigated types of pelvic cancers was dosimetrically and geometrically accurate for clinical use.en
dc.description.versionPeer revieweden
dc.format.extent8
dc.format.extent1-8
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationKemppainen, R, Suilamo, S, Ranta, I, Pesola, M, Halkola, A, Eufemio, A, Minn, H & Keyriläinen, J 2019, ' Assessment of dosimetric and positioning accuracy of a magnetic resonance imaging-only solution for external beam radiotherapy of pelvic anatomy ', Physics and Imaging in Radiation Oncology, vol. 11, pp. 1-8 . https://doi.org/10.1016/j.phro.2019.06.001en
dc.identifier.doi10.1016/j.phro.2019.06.001en_US
dc.identifier.issn2405-6316
dc.identifier.otherPURE UUID: 1c5f78fd-91cc-4566-9afe-fedb6c56d68cen_US
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/1c5f78fd-91cc-4566-9afe-fedb6c56d68cen_US
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85070485650&partnerID=8YFLogxKen_US
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/36258379/1_s2.0_S2405631618300885_main.pdfen_US
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/40019
dc.identifier.urnURN:NBN:fi:aalto-201909035061
dc.language.isoenen
dc.publisherElsevier
dc.relation.ispartofseriesPhysics and Imaging in Radiation Oncologyen
dc.relation.ispartofseriesVolume 11en
dc.rightsopenAccessen
dc.subject.keywordImage-guided radiotherapyen_US
dc.subject.keywordMRI-onlyen_US
dc.subject.keywordPosition verificationen_US
dc.subject.keywordRadiotherapyen_US
dc.titleAssessment of dosimetric and positioning accuracy of a magnetic resonance imaging-only solution for external beam radiotherapy of pelvic anatomyen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion
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