The Effect of Inter-pulse Interval on TMS Motor Evoked Potentials in Active Muscles

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Journal Title
Journal ISSN
Volume Title
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Date
2022-03-22
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Mcode
Degree programme
Language
en
Pages
9
Series
FRONTIERS IN HUMAN NEUROSCIENCE, Volume 16
Abstract
Objective: The time interval between transcranial magnetic stimulation (TMS) pulses affects evoked muscle responses when the targeted muscle is resting. This necessitates using sufficiently long inter-pulse intervals (IPIs). However, there is some evidence that the IPI has no effect on the responses evoked in active muscles. Thus, we tested whether voluntary contraction could remove the effect of the IPI on TMS motor evoked potentials (MEPs). Methods: In our study, we delivered sets of 30 TMS pulses with three different IPIs (2, 5, and 10 s) to the left primary motor cortex. These measurements were performed with the resting and active right hand first dorsal interosseous muscle in healthy participants (N = 9 and N = 10). MEP amplitudes were recorded through electromyography. Results: We found that the IPI had no significant effect on the MEP amplitudes in the active muscle (p = 0.36), whereas in the resting muscle, the IPI significantly affected the MEP amplitudes (p < 0.001), decreasing the MEP amplitude ofthe 2 s IPI. Conclusions: These results show that active muscle contraction removes the effect of the IPI on the MEP amplitude. Therefore, using active muscles in TMS motor mapping enables faster delivery of TMS pulses, reducing measurement time in novel TMS motor mapping studies.
Description
Funding Information: This work was supported by the Academy of Finland (Grant Number 325326). Publisher Copyright: Copyright © 2022 Matilainen, Soldati and Laakso.
Keywords
active muscle contraction, inter-pulse interval, motor evoked potential, motor mapping, motor threshold, TMS
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Citation
Matilainen , N , Soldati , M & Laakso , I 2022 , ' The Effect of Inter-pulse Interval on TMS Motor Evoked Potentials in Active Muscles ' , FRONTIERS IN HUMAN NEUROSCIENCE , vol. 16 , 845476 . https://doi.org/10.3389/fnhum.2022.845476