Microwave-heated γ-Alumina Applied to the Reduction of Aldehydes to Alcohols

Loading...
Thumbnail Image
Journal Title
Journal ISSN
Volume Title
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Date
2020-12-16
Major/Subject
Mcode
Degree programme
Language
en
Pages
12
6344-6355
Series
ChemCatChem, Volume 12, issue 24
Abstract
The development of cheap and robust heterogeneous catalysts for the Meerwein-Ponndorf-Verley (MPV) reduction is desirable due to the difficulties in product isolation and catalyst recovery associated with the traditional use of homogeneous catalysts for MPV. Herein, we show that microwave heated γ-Al2O3 can be used for the reduction of aldehydes to alcohols. The reaction is efficient and has a broad substrates scope (19 entries). The products can be isolated by simple filtration, and the catalyst can be regenerated. With the use of microwave heating, we can direct the heating to the catalyst rather than to the whole reaction medium. Furthermore, DFT was used to study the reaction mechanism, and we can conclude that a dual-site mechanism is operative where the aldehyde and 2-propoxide are situated on two adjacent Al sites during the reduction. Additionally, volcano plots were used to rationalize the reactivity of Al2O3 in comparison to other metal oxides.
Description
Keywords
Microwave-assisted catalysis, MPV reduction, γ-AlO
Other note
Citation
Dhokale , B , Susarrey-Arce , A , Pekkari , A , Runemark , A , Moth-Poulsen , K , Langhammer , C , Härelind , H , Busch , M , Vandichel , M & Sundén , H 2020 , ' Microwave-heated γ-Alumina Applied to the Reduction of Aldehydes to Alcohols ' , ChemCatChem , vol. 12 , no. 24 , pp. 6344-6355 . https://doi.org/10.1002/cctc.202001284