A DNA Origami-Based Chiral Plasmonic Sensing Device

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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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Date
2018-12-26
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Mcode
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Language
en
Pages
44221-44225
Series
ACS Applied Materials and Interfaces, Volume 10, issue 51
Abstract
Accurate and reliable biosensing is crucial for environmental monitoring, food safety, and diagnostics. Spatially reconfigurable DNA origami nanostructures are excellent candidates for the generation of custom sensing probes. Here we present a nanoscale biosensing device that combines the accuracy and precision of the DNA origami nanofabrication technique, unique optical responses of chiral plasmonic assemblies, and high affinity and selectivity of aptamers. This combination enables selective and sensitive detection of targets even in strongly absorbing fluids. We expect that the presented sensing scheme can be adapted to a wide range of analytes and tailored to specific needs.
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Keywords
aptamers, biosensing, chiral plasmonics, DNA origami, gold nanorods
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Citation
Huang , Y , Nguyen , K , Natarajan , A & Kuzyk , A 2018 , ' A DNA Origami-Based Chiral Plasmonic Sensing Device ' , ACS Applied Materials and Interfaces , vol. 10 , no. 51 , pp. 44221-44225 . https://doi.org/10.1021/acsami.8b19153