On the clinical utility of on-scalp MEG : A modeling study of epileptic activity source estimation

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dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorWestin, Karinen_US
dc.contributor.authorBeniczky, Sándoren_US
dc.contributor.authorPfeiffer, Christophen_US
dc.contributor.authorHämäläinen, Mattien_US
dc.contributor.authorLundqvist, Danielen_US
dc.contributor.departmentDepartment of Neuroscience and Biomedical Engineeringen
dc.contributor.organizationKarolinska Instituteten_US
dc.contributor.organizationAarhus Universityen_US
dc.date.accessioned2023-12-11T09:43:48Z
dc.date.available2023-12-11T09:43:48Z
dc.date.issued2023-12en_US
dc.descriptionPublisher Copyright: © 2023 International Federation of Clinical Neurophysiology
dc.description.abstractObjective: Epilepsy surgery requires localization of the seizure onset zone (SOZ). Today this can only be achieved by intracranial electroencephalography (iEEG). The iEEG electrode placement is guided by findings from non-invasive modalities that cannot themselves detect SOZ-generated initial seizure activity. On scalp magnetoencephalography (osMEG), with sensors placed on the scalp, demonstrates higher sensitivity than conventional MEG (convMEG) and could potentially detect early seizure activity. Here, we modeled EEG, convMEG and osMEG to compare the modalities’ ability to localize SOZ activity and to detect epileptic spikes. Methods: We modeled seizure propagation within ten epileptic networks located in the mesial and lateral temporal lobe; basal, dorsal, central and frontopolar frontal lobe; parietal and occipital lobe as well as insula and cingulum. The networks included brain regions often involved in focal epilepsy. 128-channel osMEG, convMEG, EEG and combined osMEG + EEG and convMEG + EEG were modeled, and the SOZ source estimation accuracy was quantified and compared using Student's t-test. Results: OsMEG was significantly (p-value <0.01) better than both convMEG and EEG at detecting the earliest SOZ-generated seizure activity and epileptic spikes, and better at localizing seizure activity from all epileptic networks (p < 0.01). Conclusions: Our modeling results clearly show that osMEG has an unsurpassed potential to detect both epileptic spikes and seizure activity from all simulated anatomical sites. Significance: No clinically available non-invasive technique can detect SOZ activity from all brain regions. Our study indicates that osMEG has the potential to become an important clinical tool, improving both non-invasive SOZ localization and iEEG electrode placement accuracy.en
dc.description.versionPeer revieweden
dc.format.extent13
dc.format.extent143-155
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationWestin, K, Beniczky, S, Pfeiffer, C, Hämäläinen, M & Lundqvist, D 2023, ' On the clinical utility of on-scalp MEG : A modeling study of epileptic activity source estimation ', Clinical Neurophysiology, vol. 156, pp. 143-155 . https://doi.org/10.1016/j.clinph.2023.10.006en
dc.identifier.doi10.1016/j.clinph.2023.10.006en_US
dc.identifier.issn1388-2457
dc.identifier.issn1872-8952
dc.identifier.otherPURE UUID: 8e46f7ec-9ca7-40ee-bdfe-c0e58302c04een_US
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/8e46f7ec-9ca7-40ee-bdfe-c0e58302c04een_US
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85176215653&partnerID=8YFLogxKen_US
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/129115055/On_the_clinical_utility_of_on-scalp_MEG.pdfen_US
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/124850
dc.identifier.urnURN:NBN:fi:aalto-202312117218
dc.language.isoenen
dc.publisherElsevier Ireland Ltd
dc.relation.ispartofseriesClinical Neurophysiologyen
dc.relation.ispartofseriesVolume 156en
dc.rightsopenAccessen
dc.subject.keywordEpilepsy surgeryen_US
dc.subject.keywordInstrumentationen_US
dc.subject.keywordModelingen_US
dc.subject.keywordOn-scalp magnetoencephalographyen_US
dc.subject.keywordSeizure onset zone localizationen_US
dc.titleOn the clinical utility of on-scalp MEG : A modeling study of epileptic activity source estimationen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion
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