Variable opportunities for outcrossing result in hotspots of novel genetic variation in a pathogen metapopulation

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorLaine, Anna Liisa
dc.contributor.authorBarrès, Benoit
dc.contributor.authorNumminen, Elina
dc.contributor.authorSirén, Jukka P.
dc.contributor.departmentUniversity of Helsinki
dc.contributor.departmentDepartment of Computer Science
dc.date.accessioned2019-09-25T14:12:07Z
dc.date.available2019-09-25T14:12:07Z
dc.date.issued2019-06-01
dc.description| openaire: EC/H2020/281517/EU//PATHEVOL | openaire: EC/H2020/724508/EU//RESISTANCE
dc.description.abstractMany pathogens possess the capacity for sex through outcrossing, despite being able to reproduce also asexually and/or via selfing. Given that sex is assumed to come at a cost, these mixed reproductive strategies typical of pathogens have remained puzzling. While the ecological and evolutionary benefits of outcrossing are theoretically well-supported, support for such benefits in pathogen populations are still scarce. Here, we analyze the epidemiology and genetic structure of natural populations of an obligate fungal pathogen, Podosphaera plantaginis. We find that the opportunities for outcrossing vary spatially. Populations supporting high levels of coinfection –a prerequisite of sex – result in hotspots of novel genetic diversity. Pathogen populations supporting coinfection also have a higher probability of surviving winter. Jointly our results show that outcrossing has direct epidemiological consequences as well as a major impact on pathogen population genetic diversity, thereby providing evidence of ecological and evolutionary benefits of outcrossing in pathogens.en
dc.description.versionPeer revieweden
dc.format.mimetypeapplication/pdf
dc.identifier.citationLaine , A L , Barrès , B , Numminen , E & Sirén , J P 2019 , ' Variable opportunities for outcrossing result in hotspots of novel genetic variation in a pathogen metapopulation : Spatially variable opportunities for outcrossing in an obligate pathogen ' , ELIFE , vol. 8 . https://doi.org/10.7554/eLife.47091.001en
dc.identifier.doi10.7554/eLife.47091.001
dc.identifier.issn2050-084X
dc.identifier.otherPURE UUID: 435290ee-ee0c-42b1-8a99-1bcf368952b3
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/variable-opportunities-for-outcrossing-result-in-hotspots-of-novel-genetic-variation-in-a-pathogen-metapopulation(435290ee-ee0c-42b1-8a99-1bcf368952b3).html
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85071847226&partnerID=8YFLogxK
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/37052540/elife_47091_v2.pdf
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/40447
dc.identifier.urnURN:NBN:fi:aalto-201909255468
dc.language.isoenen
dc.publisherELIFE SCIENCES PUBLICATIONS LTD
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/724508/EU//RESISTANCE
dc.relation.ispartofseriesELIFEen
dc.relation.ispartofseriesVolume 8en
dc.rightsopenAccessen
dc.subject.keywordCost of sex
dc.subject.keywordDiversity
dc.subject.keywordEpidemiology
dc.subject.keywordOutcrossing
dc.subject.keywordOverwintering
dc.subject.keywordNeuroscience(all)
dc.subject.keywordBiochemistry, Genetics and Molecular Biology(all)
dc.subject.keywordImmunology and Microbiology(all)
dc.subject.keyword113 Computer and information sciences
dc.subject.otherNeuroscience(all)en
dc.subject.otherBiochemistry, Genetics and Molecular Biology(all)en
dc.subject.otherImmunology and Microbiology(all)en
dc.subject.other113 Computer and information sciencesen
dc.titleVariable opportunities for outcrossing result in hotspots of novel genetic variation in a pathogen metapopulationen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion
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