The effect of music performance on the transcriptome of professional musicians

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorKanduri, Chakravarthien_US
dc.contributor.authorKuusi, Tuireen_US
dc.contributor.authorAhvenainen, Minnaen_US
dc.contributor.authorPhilips, Anju K.en_US
dc.contributor.authorLähdesmäki, Harrien_US
dc.contributor.authorJärvelä, Irmaen_US
dc.contributor.departmentDepartment of Computer Scienceen
dc.contributor.groupauthorProfessorship Lähdesmäki Harrien
dc.contributor.groupauthorCentre of Excellence in Molecular Systems Immunology and Physiology Research Group, SyMMysen
dc.contributor.organizationUniversity of Helsinkien_US
dc.contributor.organizationUniversity of the Arts Helsinkien_US
dc.date.accessioned2017-01-19T11:06:06Z
dc.date.issued2015en_US
dc.description.abstractMusic performance by professional musicians involves a wide-spectrum of cognitive and multi-sensory motor skills, whose biological basis is unknown. Several neuroscientific studies have demonstrated that the brains of professional musicians and non-musicians differ structurally and functionally and that musical training enhances cognition. However, the molecules and molecular mechanisms involved in music performance remain largely unexplored. Here, we investigated the effect of music performance on the genome-wide peripheral blood transcriptome of professional musicians by analyzing the transcriptional responses after a 2-hr concert performance and after a ‘music-free’ control session. The up-regulated genes were found to affect dopaminergic neurotransmission, motor behavior, neuronal plasticity, and neurocognitive functions including learning and memory. Particularly, candidate genes such as SNCA, FOS and DUSP1 that are involved in song perception and production in songbirds, were identified, suggesting an evolutionary conservation in biological processes related to sound perception/production. Additionally, modulation of genes related to calcium ion homeostasis, iron ion homeostasis, glutathione metabolism, and several neuropsychiatric and neurodegenerative diseases implied that music performance may affect the biological pathways that are otherwise essential for the proper maintenance of neuronal function and survival. For the first time, this study provides evidence for the candidate genes and molecular mechanisms underlying music performance.en
dc.description.versionPeer revieweden
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationKanduri, C, Kuusi, T, Ahvenainen, M, Philips, A K, Lähdesmäki, H & Järvelä, I 2015, ' The effect of music performance on the transcriptome of professional musicians ', Scientific Reports, vol. 5, 9506, pp. 1-7 . https://doi.org/10.1038/srep09506en
dc.identifier.doi10.1038/srep09506en_US
dc.identifier.issn2045-2322
dc.identifier.otherPURE UUID: 71e9e28e-42c8-4a13-ab3d-41e846ffdc67en_US
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/71e9e28e-42c8-4a13-ab3d-41e846ffdc67en_US
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/10464159/srep09506.pdfen_US
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/24247
dc.identifier.urnURN:NBN:fi:aalto-201701191192
dc.language.isoenen
dc.relation.ispartofseriesSCIENTIFIC REPORTSen
dc.relation.ispartofseriesVolume 5en
dc.rightsopenAccessen
dc.titleThe effect of music performance on the transcriptome of professional musiciansen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion

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