Time-based Sensor Interface for Dopamine Detection

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorOlabode, Olaitan
dc.contributor.authorKosunen, Marko
dc.contributor.authorUnnikrishnan, Vishnu
dc.contributor.authorPalomäki, Tommi
dc.contributor.authorLaurila, Tomi
dc.contributor.authorHalonen, Kari
dc.contributor.authorRyynänen, Jussi
dc.contributor.departmentDepartment of Electronics and Nanoengineering
dc.contributor.departmentJussi Ryynänen Group
dc.contributor.departmentDepartment of Electrical Engineering and Automation
dc.date.accessioned2020-11-06T11:38:36Z
dc.date.available2020-11-06T11:38:36Z
dc.date.issued2020-10
dc.description.abstractThis paper describes the design of an integrated sensor interface for dopamine detection. The sensor interface circuit fabricated in 65 nm CMOS technology utilizes a time-based analog-to-digital conversion circuit built around a ring oscillator. The circuit supports a wide input current range of±1.2 µA and sampling rate of 1 - 20 kHz, enabling sub-second detection of neurochemicals within the supported current range. Measured results with physiologically relevant dopamine concentration of 500 nM demonstrate the ability of the sensor interface circuit to detect oxidation and reduction current peaks, which provides information about the release times and redox potentials of the neurochemical. This chemical information is essential in neurostimulation treatment of neurological and neurodegenerative diseases.en
dc.description.versionPeer revieweden
dc.format.extent12
dc.format.extent3284-3296
dc.format.mimetypeapplication/pdf
dc.identifier.citationOlabode , O , Kosunen , M , Unnikrishnan , V , Palomäki , T , Laurila , T , Halonen , K & Ryynänen , J 2020 , ' Time-based Sensor Interface for Dopamine Detection ' , IEEE Transactions on Circuits and Systems - I: Regular Papers , vol. 67 , no. 10 , 9144288 , pp. 3284-3296 . https://doi.org/10.1109/TCSI.2020.3008363en
dc.identifier.doi10.1109/TCSI.2020.3008363
dc.identifier.issn1549-8328
dc.identifier.otherPURE UUID: 6b3212af-c921-4838-98e7-a45258d73402
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/6b3212af-c921-4838-98e7-a45258d73402
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85092746362&partnerID=8YFLogxK
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/44438159/Olabode_Time_based_sensor_interface_TCAS_I.pdf
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/47448
dc.identifier.urnURN:NBN:fi:aalto-202011066340
dc.language.isoenen
dc.publisherIEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC
dc.relation.ispartofseriesIEEE Transactions on Circuits and Systems - I: Regular Papersen
dc.relation.ispartofseriesVolume 67, issue 10en
dc.rightsopenAccessen
dc.subject.keywordNeurosignal acquisition
dc.subject.keywordNeurochemical sensing
dc.subject.keywordDopamine detection
dc.subject.keywordOscillator-based ADC
dc.subject.keywordBiosensors
dc.subject.keywordDLC
dc.titleTime-based Sensor Interface for Dopamine Detectionen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionacceptedVersion
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