Time-based Sensor Interface for Dopamine Detection

Loading...
Thumbnail Image
Journal Title
Journal ISSN
Volume Title
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Date
2020-10
Major/Subject
Mcode
Degree programme
Language
en
Pages
12
3284-3296
Series
IEEE Transactions on Circuits and Systems - I: Regular Papers, Volume 67, issue 10
Abstract
This paper describes the design of an integrated sensor interface for dopamine detection. The sensor interface circuit fabricated in 65 nm CMOS technology utilizes a time-based analog-to-digital conversion circuit built around a ring oscillator. The circuit supports a wide input current range of±1.2 µA and sampling rate of 1 - 20 kHz, enabling sub-second detection of neurochemicals within the supported current range. Measured results with physiologically relevant dopamine concentration of 500 nM demonstrate the ability of the sensor interface circuit to detect oxidation and reduction current peaks, which provides information about the release times and redox potentials of the neurochemical. This chemical information is essential in neurostimulation treatment of neurological and neurodegenerative diseases.
Description
Keywords
Neurosignal acquisition, Neurochemical sensing, Dopamine detection, Oscillator-based ADC, Biosensors, DLC
Other note
Citation
Olabode , O , Kosunen , M , Unnikrishnan , V , Palomäki , T , Laurila , T , Halonen , K & Ryynänen , J 2020 , ' Time-based Sensor Interface for Dopamine Detection ' , IEEE Transactions on Circuits and Systems - I: Regular Papers , vol. 67 , no. 10 , 9144288 , pp. 3284-3296 . https://doi.org/10.1109/TCSI.2020.3008363