Stronger proprioceptive BOLD-responses in the somatosensory cortices reflect worse sensorimotor function in adolescents with and without cerebral palsy

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Journal Title
Journal ISSN
Volume Title
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Date
2021-01
Major/Subject
Mcode
Degree programme
Language
en
Pages
15
Series
NeuroImage: Clinical, Volume 32
Abstract
Cerebral palsy (CP) is a motor disorder where the motor defects are partly due to impaired proprioception. We studied cortical proprioceptive responses and sensorimotor performance in adolescents with CP and their typically-developed (TD) peers. Passive joint movements were used to stimulate proprioceptors during functional magnetic resonance imaging (fMRI) session to quantify the proprioceptive responses whose associations to behavioral sensorimotor performance were also examined. Twenty-three TD (15 females, age: mean ± standard deviation 14.2 ± 2.4 years) and 18 CP (12 females, age: mean ± standard deviation, 13.8 ± 2.3 years; 12 hemiplegic, 6 diplegic) participants were included in this study. Participants’ index fingers and ankles were separately stimulated at 3 Hz and 1 Hz respectively with pneumatic movement actuators. Regions-of-interest were used to quantify BOLD-responses from the primary sensorimotor (SM1) and secondary (SII) somatosensory cortices and were compared across the groups. Associations between responses strengths and sensorimotor performance measures were also examined. Proprioceptive responses were stronger for the individuals with CP compared to their TD peers in SM1 (p < 0.001) and SII (p < 0.05) cortices contralateral to their more affected index finger. The ankle responses yielded no significant differences between the groups. The CP group had worse sensorimotor performance for hands and feet (p < 0.001). Stronger responses to finger stimulation in the dominant SM1 (p < 0.001) and both dominant and non-dominant SII (p < 0.01, p < 0.001) cortices were associated with the worse hand sensorimotor performance across all participants. Worse hand function was associated with stronger cortical activation to the proprioceptive stimulation. This association was evident both in adolescents with CP and their typically-developed controls, thus it likely reflects both clinical factors and normal variation in the sensorimotor function. The specific mechanisms need to be clarified in future studies.
Description
Funding Information: We acknowledge the computational resources provided by the Aalto Science-IT project. We would like to thank Marita Kattelus, Tuomas Tolvanen and Toni Auranen from Advanced Magnetic Imaging (AMI) Centre for assistance in the neuroimaging measurements. We would like to thank Helge Kainulainen for providing us with engineering help. We would also like to thank Anni Nora, Nina Ritari, Laura Schildt and Ida ?rma performing the cognitive testing. Motion Analysis Laboratory team in Helsinki University Hospital measuring and analysing the sensorimotor testing, including Piia Haakana, Kati Tammivuori, Sari Korhonen, Elina Ylitalo, Tuula Niemel?, Essi Marttinen-Rossi, Juha-Pekka Kulmala and Jussi Nurminen. Funding Information: This work was supported by the Academy of Finland (grants #296240, #304294, #307250 and #3327288 to HP) and ”Brain changes across the life-span” profiling funding to University of Jyväskylä (grant #311877).; Jane and Aatos Erkko Foundation and Emil Aaltonen Foundation (grant #602.274) to HP. Publisher Copyright: © 2021 The Author(s)
Keywords
Diplegia, Hemiplegia, Kinesthesia, Passive movement, SII, SM1
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Citation
Nurmi , T , Jaatela , J , Vallinoja , J , Mäenpää , H & Piitulainen , H 2021 , ' Stronger proprioceptive BOLD-responses in the somatosensory cortices reflect worse sensorimotor function in adolescents with and without cerebral palsy ' , NeuroImage: Clinical , vol. 32 , 102795 . https://doi.org/10.1016/j.nicl.2021.102795