In Search of Clinical Markers : Indicators of Exposure in Dampness and Mold Hypersensitivity Syndrome (DMHS)

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorVaali, Kirsien_US
dc.contributor.authorEkumi, Kingsley Mokubeen_US
dc.contributor.authorAndersson, Maria A.en_US
dc.contributor.authorMannerström, Marikaen_US
dc.contributor.authorHeinonen, Tuulaen_US
dc.contributor.departmentDepartment of Civil Engineeringen
dc.contributor.groupauthorPerformance in Building Design and Constructionen
dc.contributor.organizationUniversity of Helsinkien_US
dc.contributor.organizationTampere Universityen_US
dc.date.accessioned2023-04-19T06:06:02Z
dc.date.available2023-04-19T06:06:02Z
dc.date.issued2023-03en_US
dc.descriptionFunding Information: M.M. and T.H. were funded by FICAM Institute, University of Tampere, Finland. We thank Tom Böhling from Medicum Helsinki for supporting part of the laboratory costs of the study. The economic support for K.V., K.M.E., came from the Finnish Work Environmental Fund (114168). M.A.A. fundings were from The Finnish Work Environmental Fund (112286), and The Academy of Finland (TOXICPM grant number 289161). The funders had no role in the design of the study nor in the collection, analyses, or interpretation of data, in the writing of the manuscript, or in the decision to publish the results. Publisher Copyright: © 2023 by the authors.
dc.description.abstractPotential markers were sought to diagnose mold hypersensitivity. Indoor air condensed water and human macrophage THP-1 test were applied to evaluate the buildings. Basophil activation tests (BAT) were conducted and mold-specific immunoglobulins (IgE, IgG, IgA, and IgD) were measured in study subjects’ serum and feces. Exposed subjects reported markedly more symptoms from occupational air than controls. Basophils from exposed subjects died/lost activity at 225 times lower concentrations of toxic extracts from the target building than recommended in the common BAT protocol. Fecal IgG and IgD levels against Acrostalagmus luteoalbus and Aspergillus versicolor produced receiver operating curves (ROC) of 0.928 and 0.916, respectively, when plotted against the inflammation marker MRP8/14. Assaying serum immunoglobulin concentrations against the toxic Chaetomium globosum (MTAV35) from another building, a test control, did not differentiate study individuals. However, if liver metabolism produced the same core molecule from other Chaetomium globosum strains, this would explain the increased response in fecal immunoglobulins in the exposed. The altered immunoglobulin values in the samples of exposed when compared to controls revealed the route of mold exposure. The toxicity of indoor air condensed water samples, BAT and serology confirmed the severity of symptoms in the target building’s employees, supporting earlier findings of toxicity in this building.en
dc.description.versionPeer revieweden
dc.format.extent24
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationVaali, K, Ekumi, K M, Andersson, M A, Mannerström, M & Heinonen, T 2023, ' In Search of Clinical Markers : Indicators of Exposure in Dampness and Mold Hypersensitivity Syndrome (DMHS) ', Journal of Fungi, vol. 9, no. 3, 332 . https://doi.org/10.3390/jof9030332en
dc.identifier.doi10.3390/jof9030332en_US
dc.identifier.issn2309-608X
dc.identifier.otherPURE UUID: 6c751d52-3ce4-47c8-b256-69fc41f559f6en_US
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/6c751d52-3ce4-47c8-b256-69fc41f559f6en_US
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85151521172&partnerID=8YFLogxKen_US
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/106027572/jof_09_00332_v5.pdfen_US
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/120462
dc.identifier.urnURN:NBN:fi:aalto-202304192778
dc.language.isoenen
dc.publisherMDPI AG
dc.relation.ispartofseriesJournal of Fungien
dc.relation.ispartofseriesVolume 9, issue 3en
dc.rightsopenAccessen
dc.subject.keywordbasophilsen_US
dc.subject.keywordcalprotectinen_US
dc.subject.keyworddampness and mold hypersensitivityen_US
dc.subject.keywordfecalen_US
dc.subject.keywordIgDen_US
dc.subject.keywordimmunoglobulinsen_US
dc.subject.keywordmycotoxinsen_US
dc.subject.keywordsick-building syndromeen_US
dc.titleIn Search of Clinical Markers : Indicators of Exposure in Dampness and Mold Hypersensitivity Syndrome (DMHS)en
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion
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