Anti-angiogenic and anti-inflammatory activity of the summer truffle (Tuber aestivum Vittad.) extracts and a correlation with the chemical constituents identified therein

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dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorMarathe, Sandesh J.en_US
dc.contributor.authorHamzi, Wahibaen_US
dc.contributor.authorBashein, Abdulla M.en_US
dc.contributor.authorDeska, Janen_US
dc.contributor.authorSeppänen-Laakso, Tuulikkien_US
dc.contributor.authorSinghal, Rekha S.en_US
dc.contributor.authorShamekh, Salemen_US
dc.contributor.departmentDepartment of Chemistry and Materials Scienceen
dc.contributor.groupauthorBioorganic chemistryen
dc.contributor.organizationInstitute of Chemical Technologyen_US
dc.contributor.organizationUniversity of SaadDahlab Blidaen_US
dc.contributor.organizationUniversity of Tripolien_US
dc.contributor.organizationVTT Technical Research Centre of Finlanden_US
dc.contributor.organizationJuva Truffle Centeren_US
dc.date.accessioned2020-09-25T07:04:22Z
dc.date.available2020-09-25T07:04:22Z
dc.date.embargoinfo:eu-repo/date/embargoEnd/2021-09-18en_US
dc.date.issued2020-11en_US
dc.description.abstractFungi are a huge source of unexplored bioactive compounds. Owing to their biological activities, several fungi have shown commercial application in the health industry. Tuber aestivum Vittad. is one such edible fungi with an immense scope for practical biological applications. In the present study, the anti-angiogenic activity of petroleum ether and ethanol extracts of T. aestivum was investigated using the chick chorioallantoic membrane assay and compared to the positive controls silibinin and lenalidomide. Both the extracts showed a dose-dependent anti-angiogenic response. The extracts were also assessed for their anti-inflammatory potential by lipoxygenase-inhibition assay. The IC50 values for LOX inhibition assay, computed by the Boltzmann plot, were 368.5, 147.3 and 40.2 µg/mL, for the petroleum ether extract, ethanol extract, and the positive control ascorbic acid, respectively. The ethanol extract of T. aestivum showed superior anti-angiogenic and anti-inflammatory activity than the petroleum ether extract. Compositional investigation of the extracts by GC-MS revealed the presence of various bioactive compounds. The compounds were correlated to their anti-angiogenic and anti-inflammatory activity based on a meticulous literature search.en
dc.description.versionPeer revieweden
dc.format.extent9
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationMarathe, S J, Hamzi, W, Bashein, A M, Deska, J, Seppänen-Laakso, T, Singhal, R S & Shamekh, S 2020, ' Anti-angiogenic and anti-inflammatory activity of the summer truffle (Tuber aestivum Vittad.) extracts and a correlation with the chemical constituents identified therein ', Food Research International, vol. 137, 109699 . https://doi.org/10.1016/j.foodres.2020.109699en
dc.identifier.doi10.1016/j.foodres.2020.109699en_US
dc.identifier.issn0963-9969
dc.identifier.issn1873-7145
dc.identifier.otherPURE UUID: 16dcc638-0646-44d9-a8a8-dc1b5618d8ffen_US
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/16dcc638-0646-44d9-a8a8-dc1b5618d8ffen_US
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85091738405&partnerID=8YFLogxK
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/51640718/CHEM_Marathe_et_al_Anti_angiogenic_and_anti_inflammatory_activity_Food_Research_International.pdfen_US
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/46585
dc.identifier.urnURN:NBN:fi:aalto-202009255515
dc.language.isoenen
dc.publisherElsevier
dc.relation.ispartofseriesFood Research Internationalen
dc.relation.ispartofseriesVolume 137en
dc.rightsopenAccessen
dc.subject.keywordtrufflesen_US
dc.subject.keywordTuber aestivumen_US
dc.subject.keywordchick chorioallanotic-membrane (CAM) assayen_US
dc.subject.keywordanti-angiogenicen_US
dc.subject.keywordLOX-inhibitiorsen_US
dc.subject.keywordanti-inflammatoryen_US
dc.titleAnti-angiogenic and anti-inflammatory activity of the summer truffle (Tuber aestivum Vittad.) extracts and a correlation with the chemical constituents identified thereinen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
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