Simultaneous Organic and Inorganic Host-Guest Chemistry within Pillararene-Protein Cage Frameworks

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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä

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en

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7

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Chemistry: A European Journal, Volume 28, issue 11

Abstract

Supramolecular self-assembly of biomolecules provides a powerful bottom-up strategy to build functional nanostructures and materials. Among the different biomacromolecules, protein cages offer various advantages including uniform size, versatility, multi-modularity, and high stability. Additionally, protein cage crystals present confined microenvironments with well-defined dimensions. On the other hand, molecular hosts, such as cyclophanes, possess a defined cavity size and selective recognition of guest molecules. However, the successful combination of macrocycles and protein cages to achieve functional co-crystals has remained limited. In this study, we demonstrate electrostatic binding between cationic pillar[5]arenes and (apo)ferritin cages that results in porous and crystalline frameworks. The electrostatically assembled crystals present a face-centered cubic (FCC) lattice and have been characterized by means of small-angle X-ray scattering and cryo-TEM. These hierarchical structures result in a multiadsorbent framework capable of hosting both organic and inorganic pollutants, such as dyes and toxic metals, with potential application in water-remediation technologies.

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| openaire: EC/H2020/794536/EU//BiHyOMat | openaire: EC/H2020/101002258/EU//ProCrystal

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Shaukat, A, Anaya-Plaza, E, Beyeh, N K & Kostiainen, M A 2022, 'Simultaneous Organic and Inorganic Host-Guest Chemistry within Pillararene-Protein Cage Frameworks', Chemistry: A European Journal, vol. 28, no. 11, e202104341. https://doi.org/10.1002/chem.202104341