Molecular Mechanisms Involved in the Ageing of Protein Condensates

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Kemian tekniikan korkeakoulu | Bachelor's thesis
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Date

2025-09-01

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CHEM3054

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Aalto Bachelor's Programme in Science and Technology

Language

en

Pages

37

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Abstract

Protein condensates, formed through liquid-liquid phase separation, continuously cement their importance in cellular organisation and regulation. However, their long-term stability is challenged by ageing, a process in which condensates transition from liquid-like to gel-like or solid-like states with deep functional and pathological implications. This thesis reviews current research on condensate ageing, starting with the fundamentals of phase separation and the roles of protein condensates in cells. It then assesses the scope of experimental and computational techniques used to explain their behaviour. Furthermore, biological systems, environmental factors and intrinsic properties are taken into consideration. Subsequently, the thesis discusses the findings which shape our understanding of protein condensate behaviour and outlines future outlooks for research.

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Supervisor

Hummel, Michael

Thesis advisor

Tolmachev, Dmitry

Keywords

condensate ageing, liquid-liquid phase separation, neurodegenerative diseases, protein condensates, environmental and intrinsic factors

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https://urn.fi/URN:NBN:fi:aalto-202510077442

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[kand] Kemian tekniikan korkeakoulu / CHEM