Metallurgical Gallium Additions to Titanium Alloys Demonstrate a Strong Time-Increasing Antibacterial Activity without any Cellular Toxicity

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Journal Title
Journal ISSN
Volume Title
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Date
2019-05-02
Major/Subject
Mcode
Degree programme
Language
en
Pages
6
2815-2820
Series
ACS Biomaterials Science and Engineering, Volume 5, issue 6
Abstract
Orthopedic metallic devices are often related with devasting complications due to acute prosthetic joint infections. Gallium (Ga) antibacterial activity has been demonstrated by the evidence that Ga in solution ionizes in a Ga3+ trivalent form that replace Fe3+ thus arresting metabolism. However, it is not clear whether such effect is restricted only to Ga3+ release laps. Accordingly, here we investigated Ga addition into titanium alloys using metallurgical methods, thus realizing intermetallides of a very high stability that contain Ga in the range of 1, 2, 20, and 23% wt. ICP-OES analysis confirmed that Ga ions were not released from the specimens regardless of the Ga amount. These alloys ensured long-lasting Ga effect toward multidrug resistant Staphylococcus aureus, whose metabolic activity was reduced of >80% in comparison with controls. Finally, specimens cytocompatibility was confirmed by direct and indirect contact evaluations with mature osteoblasts and preosteoblasts progenitor cells.
Description
Keywords
antibacterial, biofilm, cytocompatibility, gallium, orthopedic, titanium alloy
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Citation
Cochis , A , Azzimonti , B , Chiesa , R , Rimondini , L & Gasik , M 2019 , ' Metallurgical Gallium Additions to Titanium Alloys Demonstrate a Strong Time-Increasing Antibacterial Activity without any Cellular Toxicity ' , ACS Biomaterials Science and Engineering , vol. 5 , no. 6 , pp. 2815-2820 . https://doi.org/10.1021/acsbiomaterials.9b00147