Development and characterization of Myrica esculenta plant extract-based albumin nanoparticles for anticancer activity

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dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorShukla, Monu Kumaren_US
dc.contributor.authorKaushik, Harshen_US
dc.contributor.authorTiwari, Harshitaen_US
dc.contributor.authorBehera, Chittaranjanen_US
dc.contributor.authorTonk, Rajiv Kumaren_US
dc.contributor.authorHusain, Asifen_US
dc.contributor.authorSingh, Jayen_US
dc.contributor.authorKesari, Kavindra Kumaren_US
dc.contributor.authorKumar, Deepaken_US
dc.contributor.departmentDepartment of Applied Physicsen
dc.contributor.organizationShoolini University of Biotechnology and Management Sciencesen_US
dc.contributor.organizationDrug Chemistry Research Centreen_US
dc.contributor.organizationGuru Nanak Dev University Amritsaren_US
dc.contributor.organizationDelhi Pharmaceutical Sciences and Research Universityen_US
dc.contributor.organizationJamia Hamdard Universityen_US
dc.contributor.organizationBanaras Hindu Universityen_US
dc.date.accessioned2024-07-04T09:14:35Z
dc.date.available2024-07-04T09:14:35Z
dc.date.issued2024-10-15en_US
dc.descriptionPublisher Copyright: © 2024 The Authors
dc.description.abstractMyrica esculenta plant extracts have been reported for their anticancer properties. Also, albumin has been reported as a drug carrier due to non-immunogenic nature and ability to bypass the reticuloendothelial system (RES). In this study Myrica esculenta plant extract-based albumin nanoparticles (ME-BSANPs) were characterized and prepared for cancer therapy. The objective of this study is to enhance the absorption of the phytoconstituents and to improve cancer cell selectivity that leads to apoptosis. The prepared nanoparticles were examined for their morphological characteristics, such as, size, shape, surface charge, and stability. Furthermore, the design of expert (DOE) software was used to determine the formulation parameters. The size of the synthesized nanoparticles were analyzed and images were observed in the filed emission scanning electron microscopy (FESEM). In vitro studies of these nanoparticles were tested on cancer cell line (MIA PaCa-2) and resulted to cell cytotoxicity with an increase in the level of apoptosis or programmed cell death. The study of molecular docking was reported in Myrica esculenta bark. The docking was performed with BSA to check the binding affinity because BSA-based nanoparticles embedded with plant extract may interact with cancer targets. Docking studies revealed that the plant phytoconstituents have good binding affinity to BSA, which may carry these nanoparticles to target the cancer site to trigger apoptosis. These research findings suggest that the plant extract-loaded albumin-based nanoparticles could be a new development in cancer treatment. Also, these nanoparticles showed an excellent drug delivery and anticancer activities with fewer side effects.en
dc.description.versionPeer revieweden
dc.format.extent20
dc.format.mimetypeapplication/pdfen_US
dc.identifier.citationShukla, M K, Kaushik, H, Tiwari, H, Behera, C, Tonk, R K, Husain, A, Singh, J, Kesari, K K & Kumar, D 2024, ' Development and characterization of Myrica esculenta plant extract-based albumin nanoparticles for anticancer activity ', Industrial Crops and Products, vol. 218, 118815, pp. 1-20 . https://doi.org/10.1016/j.indcrop.2024.118815en
dc.identifier.doi10.1016/j.indcrop.2024.118815en_US
dc.identifier.issn0926-6690
dc.identifier.issn1872-633X
dc.identifier.otherPURE UUID: ead97907-5f9c-4ac5-96c2-e1cf7773c935en_US
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/ead97907-5f9c-4ac5-96c2-e1cf7773c935en_US
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85196008448&partnerID=8YFLogxKen_US
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/149951634/Development_and_characterization_of_Myrica_esculenta_plant_extract-based_albumin_nanoparticles_for_anticancer_activity.pdfen_US
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/129492
dc.identifier.urnURN:NBN:fi:aalto-202407045077
dc.language.isoenen
dc.publisherElsevier
dc.relation.ispartofseriesIndustrial Crops and Products
dc.relation.ispartofseriesVolume 218, pp. 1-20
dc.rightsopenAccessen
dc.subject.keywordAnticancer activityen_US
dc.subject.keywordBovine serum albuminen_US
dc.subject.keywordDrug deliveryen_US
dc.subject.keywordMIA PaCa-2 cell lineen_US
dc.subject.keywordMyrica esculentaen_US
dc.subject.keywordNanoparticulate formulationen_US
dc.titleDevelopment and characterization of Myrica esculenta plant extract-based albumin nanoparticles for anticancer activityen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
dc.type.versionpublishedVersion
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