Deep brain stimulation of subthalamic nucleus modulates cortical auditory processing in advanced Parkinson’s Disease
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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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Date
2022-02-24
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Language
en
Pages
12
1-12
1-12
Series
PloS one, Volume 17, issue 2 February
Abstract
Deep brain stimulation (DBS) has proven its clinical efficacy in Parkinson’s disease (PD), but its exact mechanisms and cortical effects continue to be unclear. Subthalamic (STN) DBS acutely modifies auditory evoked responses, but its long-term effect on auditory cortical processing remains ambiguous. We studied with magnetoencephalography the effect of long-term STN DBS on auditory processing in patients with advanced PD. DBS resulted in significantly increased contra-ipsilateral auditory response latency difference at ~100 ms after stimulus onset compared with preoperative state. The effect is likely due to normalization of neuronal asynchrony in the auditory pathways. The present results indicate that STN DBS in advanced PD patients has long-lasting effects on cortical areas outside those confined to motor processing. Whole-head magnetoencephalography provides a feasible tool to study motor and non-motor neural networks in PD, and to track possible changes related to cortical reorganization or plasticity induced by DBS.Description
Publisher Copyright: Copyright: © 2022 Valkonen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Citation
Valkonen , K , Mäkelä , J P , Airaksinen , K , Nurminen , J , Kivisaari , R , Renvall , H & Pekkonen , E 2022 , ' Deep brain stimulation of subthalamic nucleus modulates cortical auditory processing in advanced Parkinson’s Disease ' , PloS one , vol. 17 , no. 2 , e0264333 , pp. 1-12 . https://doi.org/10.1371/journal.pone.0264333
