Brain structural alterations in autism and criminal psychopathy
Loading...
Access rights
openAccess
publishedVersion
URL
Journal Title
Journal ISSN
Volume Title
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
This publication is imported from Aalto University research portal.
View publication in the Research portal (opens in new window)
View/Open full text file from the Research portal (opens in new window)
View publication in the Research portal (opens in new window)
View/Open full text file from the Research portal (opens in new window)
Date
Major/Subject
Mcode
Degree programme
Language
en
Pages
9
Series
NeuroImage: Clinical, Volume 35, pp. 1-9
Abstract
The goal of this study was to elucidate the anatomical brain basis of social cognition through two disorders with distinctively different phenotypes of social interaction. We compared structural MR images of 20 individuals with autism spectrum disorder (ASD), 19 violent offenders with high psychopathic traits, and 19 control participants using voxel-based morphometry (VBM). Our earlier study showed lower grey matter volume (GMV) values in the insula, frontal cortex, and sensorimotor cortex of the offender group compared to controls. In the present study, the images of the ASD group revealed lower GMV in the left precuneus, right cerebellum, and right precentral gyrus in comparison with controls. The comparison between the offender and ASD groups showed lower GMV values for the right temporal pole and left inferior frontal gyrus in the offender group. There was also an overlap of both disorders in the right pre-central cortex, showing lower GMV compared to controls. Our findings suggest structural differences between violent offenders with high psychopathy traits and ASD individuals in the frontotemporal social brain network areas, previously associated with empathy. We also provide evidence of similar abnormal structures in the motor cortex for both of these disorders, possibly related to uniting issues of social cognition.Description
Funding Information: Jari Tiihonen has participated in research projects funded by grants from Janssen-Cilag and Eli Lilly to his employing institution, and has been a consultant and/or advisor to and/or has received honoraria from: Eli Lilly, Evidera, Janssen-Cilag, Lundbeck, Orion, Otsuka, Mediuutiset, Sidera, and Sunovion. Funding Information: The study was supported by the Academy of Finland (grants numbers 294897 and 332225, to L.N.), Valon Vuoksi Foundation (grants to L.S. and L.L.) and Turku Collegium for Science and Medicine, University of Turku (to L.S.). Publisher Copyright: © 2022 The Authors
Other note
Citation
Noppari, T, Sun, L, Lukkarinen, L, Putkinen, V, Tani, P, Lindberg, N, Saure, E, Lauerma, H, Tiihonen, J, Venetjoki, N, Salomaa, M, Rautio, P, Hirvonen, J, Salmi, J & Nummenmaa, L 2022, 'Brain structural alterations in autism and criminal psychopathy', NeuroImage: Clinical, vol. 35, 103116, pp. 1-9. https://doi.org/10.1016/j.nicl.2022.103116