A multicenter study of the early detection of synaptic dysfunction in Mild Cognitive Impairment using magnetoencephalography-derived functional connectivity
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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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Date
2015
Major/Subject
Mcode
Degree programme
Language
en
Pages
103-109
Series
NEUROIMAGE. CLINICAL, Volume 9
Abstract
Synaptic disruption is an early pathological sign of the neurodegeneration of Dementia of the Alzheimer's type (DAT). The changes in network synchronization are evident in patients with Mild Cognitive Impairment (MCI) at the group level, but there are very few Magnetoencephalography (MEG) studies regarding discrimination at the individual level. In an international multicenter study, we used MEG and functional connectivity metrics to discriminate MCI from normal aging at the individual person level. A labeled sample of features (links) that distinguished MCI patients from controls in a training dataset was used to classify MCI subjects in two testing datasets from four other MEG centers. We identified a pattern of neuronal hypersynchronization in MCI, in which the features that best discriminated MCI were fronto-parietal and interhemispheric links. The hypersynchronization pattern found in the MCI patients was stable across the five different centers, and may be considered an early sign of synaptic disruption and a possible preclinical biomarker for MCI/DAT.Description
Keywords
Magnetoencephalography, Mild Cognitive Impairment, Functional connectivity, Data mining, Machine learning, Synaptic dysfunction, Multicenter study
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Citation
Maestú, F, Peña, J-M, Garcés, P, González, S, Bajo, R, Bagic, A, Cuesta, P, Funke, M, Mäkelä, J P, Menasalvas, E, Nakamura, A, Parkkonen, L, López, M E, del Pozo, F, Sudre, G, Zamrini, E, Pekkonen, E, Henson, R N & Becker, J T 2015, ' A multicenter study of the early detection of synaptic dysfunction in Mild Cognitive Impairment using magnetoencephalography-derived functional connectivity ', NEUROIMAGE. CLINICAL, vol. 9, pp. 103-109 . https://doi.org/10.1016/j.nicl.2015.07.011