Crosstalk between long noncoding RNA and microRNA in Cancer
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Volume Title
A2 Katsausartikkeli tieteellisessä aikakauslehdessä
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Date
2023-08
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Mcode
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Language
en
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Cellular Oncology
Abstract
miRNAs and lncRNAs play a central role in cancer-associated gene regulations. The dysregulated expression of lncRNAs has been reported as a hallmark of cancer progression, acting as an independent prediction marker for an individual cancer patient. The interplay of miRNA and lncRNA decides the variation of tumorigenesis that could be mediated by acting as sponges for endogenous RNAs, regulating miRNA decay, mediating intra-chromosomal interactions, and modulating epigenetic components. This paper focuses on the influence of crosstalk between lncRNA and miRNA on cancer hallmarks such as epithelial-mesenchymal transition, hijacking cell death, metastasis, and invasion. Other cellular roles of crosstalks, such as neovascularization, vascular mimicry, and angiogenesis were also discussed. Additionally, we reviewed crosstalk mechanism with specific host immune responses and targeting interplay (between lncRNA and miRNA) in cancer diagnosis and management. Graphic Abstract: [Figure not available: see fulltext.].Description
Funding Information: We thank Aalto University for providing open-access support. NP would like to acknowledge Finnish cultural foundation (Varsinais-Suomi regional fund.) Publisher Copyright: © 2023, The Author(s).
Keywords
Angiogenesis, Cancer, Epithelial-mesenchymal transition, Long-noncoding RNA, Metastasis, MicroRNA, Neovascularization, Vascular mimicry
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Citation
Bhattacharjee, R, Prabhakar, N, Kumar, L, Bhattacharjee, A, Kar, S, Malik, S, Kumar, D, Ruokolainen, J, Negi, A, Jha, N K & Kesari, K K 2023, ' Crosstalk between long noncoding RNA and microRNA in Cancer ', Cellular Oncology, vol. 46, no. 4, pp. 885-908 . https://doi.org/10.1007/s13402-023-00806-9
