Atopic asthma after rhinovirus-induced wheezing is associated with DNA methylation change in the SMAD3 gene promoter

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Journal Title
Journal ISSN
Volume Title
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
Date
2018-05-05
Major/Subject
Mcode
Degree programme
Language
en
Pages
6
1735-1740
Series
Allergy, Volume 73, issue 8
Abstract
Abstract Children with rhinovirus-induced severe early wheezing have an increased risk of developing asthma later in life. The exact molecular mechanisms for this association are still mostly unknown. To identify potential changes in the transcriptional and epigenetic regulation in rhinovirus-associated atopic or nonatopic asthma, we analyzed a cohort of 5-year-old children (n = 45) according to the virus etiology of the first severe wheezing episode at the mean age of 13 months and to 5-year asthma outcome. The development of atopic asthma in children with early rhinovirus-induced wheezing was associated with DNA methylation changes at several genomic sites in chromosomal regions previously linked to asthma. The strongest changes in atopic asthma were detected in the promoter region of SMAD3 gene at chr 15q22.33 and introns of DDO/METTL24 genes at 6q21. These changes were validated to be present also at the average age of 8 years.
Description
Keywords
asthma, epigenome, rhinovirus, transcriptome, wheezing
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Citation
Lund, R J, Osmala, M, Malonzo, M, Lukkarinen, M, Leino, A, Salmi, J, Vuorikoski, S, Turunen, R, Vuorinen, T, Akdis, C, Lähdesmäki, H, Lahesmaa, R & Jartti, T 2018, ' Atopic asthma after rhinovirus-induced wheezing is associated with DNA methylation change in the SMAD3 gene promoter ', Allergy, vol. 73, no. 8, pp. 1735-1740 . https://doi.org/10.1111/all.13473