Dynamics of DNA Origami Lattices

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A2 Katsausartikkeli tieteellisessä aikakauslehdessä
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2023-01-18

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Department of Bioproducts and Biosystems

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en

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Bioconjugate Chemistry, Volume 34, issue 1, pp. 18–29

Abstract

Hierarchical assembly of programmable DNA frameworks-such as DNA origami-paves the way for versatile nanometer-precise parallel nanopatterning up to macroscopic scales. As of now, the rapid evolution of the DNA nanostructure design techniques and the accessibility of these methods provide a feasible platform for building highly ordered DNA-based assemblies for various purposes. So far, a plethora of different building blocks based on DNA tiles and DNA origami have been introduced, but the dynamics of the large-scale lattice assembly of such modules is still poorly understood. Here, we focus on the dynamics of two-dimensional surface-assisted DNA origami lattice assembly at mica and lipid substrates and the techniques for prospective three-dimensional assemblies, and finally, we summarize the potential applications of such systems.

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Funding Information: We acknowledge financial support by Emil Aaltonen Foundation, Sigrid Jusélius Foundation, Jane and Aatos Erkko Foundation, Aalto University School of Chemical Engineering, Finnish Cultural Foundation (Maili Autio Fund), and Deutsche Forschungsgemeinschaft (DFG) under grant number 469036492. This work was carried out under the Academy of Finland Centers of Excellence Program (2022–2029) in Life-Inspired Hybrid Materials (LIBER), project number (346110). Publisher Copyright: © 2022 The Authors. Published by American Chemical Society.

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DOI

10.1021/acs.bioconjchem.2c00359

Citation

Julin, S, Keller, A & Linko, V 2023, ' Dynamics of DNA Origami Lattices ', Bioconjugate Chemistry, vol. 34, no. 1, pp. 18–29 . https://doi.org/10.1021/acs.bioconjchem.2c00359

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https://urn.fi/URN:NBN:fi:aalto-202301251515

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[article-cris] Kemian tekniikan korkeakoulu / CHEM