In Situ Generation of Chiroptically-Active Gold-Peptide Superstructures Promoted by Iodination

dc.contributorAalto-yliopistofi
dc.contributorAalto Universityen
dc.contributor.authorPigliacelli, Claudia
dc.contributor.authorSanjeeva, Kavitha Buntara
dc.contributor.authorNonappa
dc.contributor.authorPizzi, Andrea
dc.contributor.authorGori, Alessandro
dc.contributor.authorBaldelli Bombelli, Francesca
dc.contributor.authorMetrangolo, Pierangelo
dc.contributor.departmentMolecular Materials
dc.contributor.departmentPolitecnico di Milano
dc.contributor.departmentDepartment of Bioproducts and Biosystems
dc.contributor.departmentIstituto di Chimica del Riconoscimento Molecolare
dc.contributor.departmentDepartment of Applied Physics
dc.date.accessioned2019-01-30T15:11:15Z
dc.date.available2019-01-30T15:11:15Z
dc.date.issued2019-02-26
dc.description| openaire: EC/H2020/789815/EU//MINIRES doi: 10.1021/acsnano.8b08805
dc.description.abstractPeptide-mediated routes to the synthesis of plasmonic nanoparticles have been drawing increasing attention for the development of chiroptically active nanoscale architectures. However, designing a multifunctional peptide able to drive the formation of structurally defined nanomaterials endowed with specific functionalities is still challenging. In this work, iodination has been devised as a strategy to strengthen Au-reduction capability of the amyloidogenic peptide DFNKF and combine it with its distinctive self-assembly features. Thanks to the Au-mediated C - I activation on the phenylalanine iodobenzenes, the peptides yield efficient Au-reduction ability promoting the synthesis of Au nanoparticles, and simultaneously working as templates for their spontaneous self-assembly into spherical superstructures endowed with chiroptical activities. The reaction occurs in situ through a one-pot process in aqueous media. The generality of this approach has been demonstrated using an iodinated derivative of the peptide KLVFF, which also showed reducing and templating abilities forming chiroptically active helical superstructures decorated with Au nanoparticles.en
dc.description.versionPeer revieweden
dc.format.mimetypeapplication/pdf
dc.identifier.citationPigliacelli , C , Sanjeeva , K B , Nonappa , Pizzi , A , Gori , A , Baldelli Bombelli , F & Metrangolo , P 2019 , ' In Situ Generation of Chiroptically-Active Gold-Peptide Superstructures Promoted by Iodination ' , ACS Nano , vol. 13 , no. 2 , pp. 2158–2166 . https://doi.org/10.1021/acsnano.8b08805en
dc.identifier.doi10.1021/acsnano.8b08805
dc.identifier.issn1936-0851
dc.identifier.issn1936-086X
dc.identifier.otherPURE UUID: d5325ac0-7b7d-4e8b-a856-7889e2b93282
dc.identifier.otherPURE ITEMURL: https://research.aalto.fi/en/publications/d5325ac0-7b7d-4e8b-a856-7889e2b93282
dc.identifier.otherPURE LINK: http://www.scopus.com/inward/record.url?scp=85060365189&partnerID=8YFLogxK
dc.identifier.otherPURE FILEURL: https://research.aalto.fi/files/32329877/acsnano.8b08805.pdf
dc.identifier.urihttps://aaltodoc.aalto.fi/handle/123456789/36305
dc.identifier.urnURN:NBN:fi:aalto-201901301475
dc.language.isoenen
dc.publisherAMERICAN CHEMICAL SOCIETY
dc.relationinfo:eu-repo/grantAgreement/EC/H2020/789815/EU//MINIRES doi: 10.1021/acsnano.8b08805
dc.relation.ispartofseriesACS Nanoen
dc.rightsopenAccessen
dc.subject.keywordchiroptical
dc.subject.keywordgold
dc.subject.keywordiodine
dc.subject.keywordnanoparticles
dc.subject.keywordpeptide
dc.subject.keywordsuperstructures
dc.titleIn Situ Generation of Chiroptically-Active Gold-Peptide Superstructures Promoted by Iodinationen
dc.typeA1 Alkuperäisartikkeli tieteellisessä aikakauslehdessäfi
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