Enantioconvergent Biocatalytic Redox Isomerization
Loading...
Access rights
openAccess
acceptedVersion
URL
Journal Title
Journal ISSN
Volume Title
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
This publication is imported from Aalto University research portal.
View publication in the Research portal (opens in new window)
View/Open full text file from the Research portal (opens in new window)
View publication in the Research portal (opens in new window)
View/Open full text file from the Research portal (opens in new window)
Authors
Date
Major/Subject
Mcode
Degree programme
Language
en
Pages
6
Series
Angewandte Chemie - International Edition, Volume 57, issue 37, pp. 12151-12156
Abstract
Alcohol dehydrogenases can act as powerful catalysts in the preparation of optically pure γ‐hydroxy‐δ‐lactones by means of an enantioconvergent dynamic redox isomerization of readily available Achmatowicz‐type pyranones. Imitating the traditionally metal‐mediated “borrowing hydrogen” approach to shuffle hydrides across molecular architectures and interconvert functional groups, this chemoinspired and purely biocatalytic interpretation effectively expands the enzymatic toolbox and provides new opportunities in the assembly of multienzyme cascades and tailor‐made cellular factories.Description
Other note
Citation
Liu, Y, Merten, C & Deska, J 2018, 'Enantioconvergent Biocatalytic Redox Isomerization', Angewandte Chemie - International Edition, vol. 57, no. 37, pp. 12151-12156. https://doi.org/10.1002/anie.201804911