Viral pathogenesis of SARS-CoV-2 infection and male reproductive health
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Journal Title
Journal ISSN
Volume Title
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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Date
2021-01-20
Major/Subject
Mcode
Degree programme
Language
en
Pages
1
200347
200347
Series
OPEN BIOLOGY, Volume 11, issue 1
Abstract
Coronavirus disease 2019 (COVID-19) has emerged as a new public health crisis, threatening almost all aspects of human life. Originating in bats, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is transmitted to humans through unknown intermediate hosts, where it is primarily known to cause pneumonia-like complications in the respiratory system. Organ-to-organ transmission has not been ruled out, thereby raising the possibility of the impact of SARS-CoV-2 infection on multiple organ systems. The male reproductive system has been hypothesized to be a potential target of SARS-CoV-2 infection, which is supported by some preliminary evidence. This may pose a global threat to male fertility potential, as men are more prone to SARS-CoV-2 infection than women, especially those of reproductive age. Preliminary reports have also indicated the possibility of sexual transmission of SARS-CoV-2. It may cause severe complications in infected couples. This review focuses on the pathophysiology of potential SARS-CoV-2 infection in the reproductive organs of males along with their invasion mechanisms. The risks of COVID-19 on male fertility as well as the differences in vulnerability to SARS-CoV-2 infection compared with females have also been highlighted.Description
Keywords
ACE2, COVID-19, fertility, male reproduction, SARS-CoV-2 infection, testicular damage
Other note
Citation
Roychoudhury , S , Das , A , Jha , N K , Kesari , K K , Roychoudhury , S , Jha , S K , Kosgi , R , Choudhury , A P , Lukac , N , Madhu , N R , Kumar , D & Slama , P 2021 , ' Viral pathogenesis of SARS-CoV-2 infection and male reproductive health ' , OPEN BIOLOGY , vol. 11 , no. 1 , 200347 , pp. 200347 . https://doi.org/10.1098/rsob.200347
