Stable Levels of Antibodies Against Unrelated Toxoid Vaccines After COVID-19 : COVID-19 Infection Does Not Affect Toxoid Vaccine Antibody Levels
Loading...
Access rights
openAccess
publishedVersion
URL
Journal Title
Journal ISSN
Volume Title
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
This publication is imported from Aalto University research portal.
View publication in the Research portal (opens in new window)
View/Open full text file from the Research portal (opens in new window)
Other link related to publication (opens in new window)
View publication in the Research portal (opens in new window)
View/Open full text file from the Research portal (opens in new window)
Other link related to publication (opens in new window)
Date
2024-02-07
Department
Major/Subject
Mcode
Degree programme
Language
en
Pages
14
Series
Pathogens and Immunity, Volume 8, issue 2, pp. 74-87
Abstract
Background: Lymphopenia is common in COVID-19. This has raised concerns that COVID-19 could affect the immune system akin to measles infection, which causes immune amnesia and a reduction in protective antibodies. Methods: We recruited COVID-19 patients (n = 59) in Helsinki, Finland, and collected plasma samples on 2 to 3 occasions during and after infection. We measured IgG antibodies to diphtheria toxin, tetanus toxoid, and pertussis toxin, along with total IgG, SARS-CoV-2 spike protein IgG, and neutralizing antibodies. We also surveyed the participants for up to 17 months for long-term impaired olfaction as a proxy for prolonged post-acute COVID-19 symptoms. Results: No significant differences were found in the unrelated vaccine responses while the serological response against COVID-19 was appropriate. During the acute phase of the disease, the SARS-CoV-2 IgG levels were lower in outpatients when compared to inpatients. SARS-CoV-2 serology kinetics matched expectations. In the acute phase, anti-tetanus and anti-diphtheria IgG levels were lower in patients with prolonged impaired olfaction during follow up than in those without. Conclusions: We could not detect significant decline in overall humoral immunity during or after COVID-19 infection. In severe COVID-19, there appears to be a temporary decline in total IgG levels.Description
Publisher Copyright: © 2024 The Authors.
Keywords
Antibodies, COVID-19, Humoral, Immunity, Post-acute COVID-19 syndrome, Vaccines
Other note
Citation
Jokiranta, S T, Miettinen, S, Salonen, S, Kareinen, L, Uusitalo, R, Korhonen, E M, Virtanen, J, Kivistö, I, Aaltonen, K, Mosselhy, D A, Lääveri, T, Kantele, A, Arstila, T P, Jarva, H, Vapalahti, O, Heinonen, S & Kekäläinen, E 2024, ' Stable Levels of Antibodies Against Unrelated Toxoid Vaccines After COVID-19 : COVID-19 Infection Does Not Affect Toxoid Vaccine Antibody Levels ', Pathogens and Immunity, vol. 8, no. 2, pp. 74-87 . https://doi.org/10.20411/pai.v8i2.627