Radiolabeled Molecular Imaging Probes for the In Vivo Evaluation of Cellulose Nanocrystals for Biomedical Applications
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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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Date
2019-02-11
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en
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10
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Biomacromolecules, Volume 20, issue 2, pp. 674-683
Abstract
Cellulose nanocrystals (CNCs) have remarkable potential to improve the delivery of diagnostic and therapeutic agents to tumors; however, the in vivo studies on CNC biodistribution are still limited. We developed CNC-based imaging probes for the in vitro and in vivo evaluation using two labeling strategies: site-specific hydrazone linkage to the terminal aldehyde of the CNC and nonsite-specific activation using 1,1′-carbonyldiimidazole (CDI). The in vivo behavior of unmodified CNC, DOTA-CNC (ald.), and DOTA-CNC (OH) was investigated in healthy and 4T1 breast cancer mouse models. They displayed good biocompatibility in cell models. Moreover, the biodistribution profile and SPECT/CT imaging confirmed that the accumulation of 111 In-labeled DOTA-CNC (ald.) and 111 In-DOTA-CNC (OH) was primarily in hepatic, splenic, and pulmonary ducts in accordance with the clearance of nontargeted nanoparticles. The developed CNC imaging probes can be used to obtain information with noninvasive imaging on the behavior in vivo to guide structural optimization for targeted delivery.Description
Tässä on AKAa muttei meidän projekti koodeja, tai vielä systeemissä niitä.
Keywords
DRUG-DELIVERY, SILICA NANOPARTICLES, SURFACE MODIFICATION, GOLD NANOPARTICLES, CANCER, CYTOTOXICITY, CHARGE, ANALOG, VITRO, SHAPE
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Imlimthan, S, Otaru, S, Keinänen, O, Correia, A, Lintinen, K, Santos, H A, Airaksinen, A J, Kostiainen, M & Sarparanta, M 2019, ' Radiolabeled Molecular Imaging Probes for the In Vivo Evaluation of Cellulose Nanocrystals for Biomedical Applications ', Biomacromolecules, vol. 20, no. 2, pp. 674-683 . https://doi.org/10.1021/acs.biomac.8b01313