Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations
Loading...
Access rights
openAccess
publishedVersion
URL
Journal Title
Journal ISSN
Volume Title
A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
This publication is imported from Aalto University research portal.
View publication in the Research portal (opens in new window)
View/Open full text file from the Research portal (opens in new window)
Other link related to publication (opens in new window)
View publication in the Research portal (opens in new window)
View/Open full text file from the Research portal (opens in new window)
Other link related to publication (opens in new window)
Date
2022-09-16
Major/Subject
Mcode
Degree programme
Language
en
Pages
21
Series
iScience, Volume 25, issue 9, pp. 1-21
Abstract
Neuronal oscillations, their inter-areal synchronization, and scale-free dynamics constitute fundamental mechanisms for cognition by regulating communication in neuronal networks. These oscillatory dynamics have large inter-individual variability that is partly heritable. We hypothesized that this variability could be partially explained by genetic polymorphisms in neuromodulatory genes. We recorded resting-state magnetoencephalography (MEG) from 82 healthy participants and investigated whether oscillation dynamics were influenced by genetic polymorphisms in catechol-O-methyltransferase (COMT) Val158Met and brain-derived neurotrophic factor (BDNF) Val66Met. Both COMT and BDNF polymorphisms influenced local oscillation amplitudes and their long-range temporal correlations (LRTCs), while only BDNF polymorphism affected the strength of large-scale synchronization. Our findings demonstrate that COMT and BDNF genetic polymorphisms contribute to inter-individual variability in neuronal oscillation dynamics. Comparison of these results to computational modeling of near-critical synchronization dynamics further suggested that COMT and BDNF polymorphisms influenced local oscillations by modulating the excitation-inhibition balance according to the brain criticality framework.Description
Funding Information: This work was supported by the Jane and Aatos Erkko Foundation , by the Academy of Finland ( SA 1266402 , 1267030 to S.P., SA 1266745 , 1296304 to J.M.P., and SA 1294761 to J.S.). Publisher Copyright: © 2022 The Authors
Keywords
Biological sciences, Cognitive neuroscience, Neuroscience
Other note
Citation
Simola, J, Siebenhühner, F, Myrov, V, Kantojärvi, K, Paunio, T, Palva, J M, Brattico, E & Palva, S 2022, ' Genetic polymorphisms in COMT and BDNF influence synchronization dynamics of human neuronal oscillations ', iScience, vol. 25, no. 9, 104985, pp. 1-21 . https://doi.org/10.1016/j.isci.2022.104985