Human ROBO1 regulates interaural interaction in auditory pathways
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A1 Alkuperäisartikkeli tieteellisessä aikakauslehdessä
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en
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Journal of Neuroscience, Volume 32, issue 3, pp. 966-971
Abstract
In rodents, the Robo1 gene regulates midline crossing of major nerve tracts, a fundamental property of the mammalian CNS. However, the neurodevelopmental function of the human ROBO1 gene remains unknown, apart from a suggested role in dyslexia. We therefore studied axonal crossing with a functional approach, based on magnetoencephalography, in 10 dyslexic individuals who all share the same rare, weakly expressing haplotype of the ROBO1 gene. Auditory-cortex responses were recorded separately to left- and right-ear sounds that were amplitude modulated at different frequencies. We found impaired interaural interaction that depended on the ROBO1 in a dose-dependent manner. Our results indicate that normal crossing of the auditory pathways requires an adequate ROBO1 expression level.Description
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Lamminmäki, S, Massinen, S, Nopola-Hemmi, J, Kere, J & Hari, R 2012, 'Human ROBO1 regulates interaural interaction in auditory pathways', Journal of Neuroscience, vol. 32, no. 3, pp. 966-971. https://doi.org/10.1523/JNEUROSCI.4007-11.2012